Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-772-0
CAS number: 72-17-3
The test article, SY-83, was evaluated for primary dermal irritation
potential when applied to 2 intact and 2 abraded test sites on the skin
of each of 6 albino rabbits and covered with impervious bandages for 24
hours. These 24 test sites were evaluated for erythema, edema, and other
lesions at 30 to 60 minutes after test article removal. This study was
designed to comply with the procedures described in the EPA/OPP
Guidelines, 1982. The following were observed at 30 to 60 minutes after
test article removal: Severe erythema was observed at all test sites on
3 animals, and at both abraded sites on 2 other animals and at one
intact site .on one of these 2 animals. Moderate to severe erythema was
observed at all test sites on one animal, and at one or both intact
sites on 2 animals. Severe edema was observed at all test sites on 5
animals and at one intact site and one abraded site on the sixth animal.
Slight edema was observed at the other 2 sites on the sixth animal.
Blanching was observed at both abraded sites on all animals and at both
intact sites on 5 of these animals. Yellow-brown color of the skin was
observed at all sites on 3 animals and at either 2 or 3 test sites on 2
animals. A red exudate was observed at one intact site on one animal.
Skin was missing at all test sites on one animal, at one intact and both
abraded sites on one animal, and at one intact site or one abraded site
on 2 other animals. No other dermal reactions were observed during the
study. This study was terminated after the 30- to 60-minute evaluations
upon the recommendation of an attending veterinarian due to the
severity of the reactions observed. No abnormal clinical signs were
observed and no mortalities occurred prior to sacrifice after the 30- to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again