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EC number: 201-993-5 | CAS number: 90-43-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study, procedure similar to current guideline but without additional strain for the detection of crosslinking agents. No test article purity is given in the study report.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- secondary source
- Title:
- O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
- Author:
- Bomhard, E. M. et al.
- Year:
- 2 002
- Bibliographic source:
- Crit. Rev. Toxicol. 32(6):551-626
- Reference Type:
- secondary source
- Title:
- Analysis of Genotoxicity and the Carcinogenic Mode of Action for Ortho-Phenylphenol
- Author:
- Brusick, D.
- Year:
- 2 005
- Bibliographic source:
- Environ Mol Mutagen 45:460-481
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- (1997)
- Deviations:
- yes
- Remarks:
- no additional strain for the detection of crosslinking agents was included into this study and no test substance purity is given
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Biphenyl-2-ol
- EC Number:
- 201-993-5
- EC Name:
- Biphenyl-2-ol
- Cas Number:
- 90-43-7
- Molecular formula:
- C12H10O
- IUPAC Name:
- [1,1'-biphenyl]-2-ol
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): test article ID 02290
- Physical state: white crystalline solid
- Analytical purity: no data
- Storage condition of test material: room temperature
Constituent 1
Method
- Target gene:
- his operon
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- CO-factor supplemented liver S9 homogenate from Aroclor 1254 induced male Sprague Dawley rats and male Golden Syrian hamsters
- Test concentrations with justification for top dose:
- 33, 67, 100, 333 and 667 (-S-9) or 1000 µg/plate (+S-9)
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: acetone
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- 2-nitrofluorene
- sodium azide
- other: 2-aminoanthracene
- Remarks:
- +S9: 2-Aminoanthracene 0.5 µg/plate (all strains); -S9: 2-nitrofluorene 1 µg/plate (TA98, TA1538), sodium azide 1 µg/plate (TA100, TA1535), 9-aminocacridine 75 µg/plate (TA1537)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 3 plates in one experiment
DETERMINATION OF CYTOTOXICITY
- Method: evaluation of bacterial background lawn - Evaluation criteria:
- For a test article to be evaluated as positive, it must cause at least a doubling in the mean revertants per plate of at least one tester strain. This increase in the mean number of revertants per plate must be accomponied by a dose response to increasing concentrations of the test article. If the study is to be judged positive solely on the basis of a dose-responsive, less than 3-fold increase in TA1537 or TA1538, the response must be confirmed in a repeat experiment.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: TA98: at 667 µg/plate (-S9) and 100 µg/plate (+S9); TA100: at 667 µg/plate (-S9/+S9),
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS:
None stated in the study report.
RANGE-FINDING/SCREENING STUDIES:
In a range-finding study with TA100 (+S9 and -S9) concentrations of 10-10,000 µg/plate in half-log steps were tested. The test revealed cytotoxicity at concentrations of 1000 µg/plate and above with metabolic activation and at 667 µg/plate and above without metabolic activation.
ADDITIONAL INFORMATION ON CYTOTOXICITY:
No positive responses were seen with tester strains TA100 and TA98 in the presence or absence of microsomal enzymes. Due to excessive cytotoxicity, the complete assay was repeated with a different dose range, but no positive reactions were noted. The test was also negative in TA1535, TA1537, and TA1538, with or without metabolic activation. The respective positive controls caused a strong increase in the number of revertants. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 1: Results of the definite assay with tester strains TA98 and TA100 with and without metabolic activation
Dose [µg/plate] |
TA98 |
TA100 |
Metabolic activation: none |
||
Vehicle control* |
17±4 |
117±13 |
3.3 |
14±2 |
108±14 |
10 |
14±4 |
111±17 |
33 |
16±3 |
125±21 |
100 |
11±3 |
122±18 |
200 |
14±2 |
102±8 |
Positive control** |
196±15 |
836±79 |
Metabolic activation: rat liver S9 |
||
Vehicle control* |
19±7 |
148±17 |
3.3 |
- |
136±1 |
10 |
21±3 |
137±10 |
33 |
20±2 |
129±1 |
100 |
19±5 |
146±11 |
333 |
15±3 |
108±12 |
500 |
12±2 |
- |
Positive control** |
644±43 |
846±18 |
Metabolic activation: hamster liver S9 |
||
Vehicle control* |
20±3 |
128±5 |
10 |
20±2 |
145±16 |
33 |
18±6 |
148±6 |
100 |
24±3 |
155±2 |
333 |
14±2 |
138±14 |
500 |
20±9 |
95±10 |
Positive control** |
1052±96 |
995±70 |
*Vehicle control: acetone (all strains +S9 and -S9)
**Positive controls: +S9: 2-aminoanthracene 0.5 µg/plate (TA98, TA100); -S9: 2-nitrofluorene 1 µg/plate (TA98) and sodium azide 1 µg/plate (TA100)
Table 2: Results of the definite assay with tester strains TA1535, TA1537 and TA1538 with and without metabolic activation
Dose [µg/plate] |
TA1535 |
TA1537 |
TA1538 |
Metabolic activation: none |
|||
Vehicle control* |
15±3 |
6±2 |
10±4 |
10 |
10±1 |
7±3 |
7±3 |
33 |
12±3 |
7±3 |
7±2 |
100 |
9±1 |
7±3 |
7±1 |
250 |
9±3 |
4±3 |
9±2 |
500 |
3±1 |
0±0 |
0±1 |
Positive control** |
417±25 |
243±41 |
447±38 |
Metabolic activation: rat liver S9 |
|||
Vehicle control* |
13±8 |
13±4 |
13±4 |
10 |
11±2 |
9±0 |
13±2 |
33 |
15±5 |
12±3 |
12±4 |
100 |
12±2 |
10±2 |
14±5 |
333 |
11±3 |
7±3 |
12±1 |
667 |
2±1 |
0±1 |
3±1 |
Positive control** |
44±6 |
40±16 |
532±42 |
Metabolic activation: hamster liver S9 |
|||
Vehicle control* |
12±3 |
7±1 |
13±2 |
10 |
13±7 |
11±1 |
12±4 |
33 |
13±2 |
10±3 |
13±6 |
100 |
12±3 |
6±1 |
10±2 |
333 |
12±4 |
8±1 |
11±2 |
667 |
4±2 |
1±1 |
4±3 |
Positive control** |
77±1 |
92±10 |
1212±62 |
*Vehicle control: acetone (all strains +S9 and -S9)
**Positive controls: +S9: 2-aminoanthracene 0.5 µg/plate (TA1535, TA11537, TA1538); -S9: sodium azide 1 µg/plate (TA1535), 9-aminoacridine 75 µg/plate (TA1537) and 2-nitrofluorene 1 µg/plate (TA1538)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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