Registration Dossier
Registration Dossier
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EC number: 201-993-5 | CAS number: 90-43-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1952
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, no guideline followed
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 952
- Reference Type:
- secondary source
- Title:
- O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
- Author:
- Bomhard, E. M. et al.
- Year:
- 2 002
- Bibliographic source:
- Crit. Rev. Toxicol. 32(6):551-626
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- OPP was tested on 200 unselected human subjects (100 males and 100 females) by means of the repeated patch test.
- GLP compliance:
- no
Test material
- Reference substance name:
- Biphenyl-2-ol
- EC Number:
- 201-993-5
- EC Name:
- Biphenyl-2-ol
- Cas Number:
- 90-43-7
- Molecular formula:
- C12H10O
- IUPAC Name:
- [1,1'-biphenyl]-2-ol
Constituent 1
- Specific details on test material used for the study:
- 5 % solution in sesame oil
Method
- Type of population:
- not specified
- Subjects:
- - Number of subjects exposed: 200 in total
- Sex: 100 males and 100 females - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Vehicle / solvent: 5 % solution in sesame oil
- Concentrations: Induction/Challenge: 5 %
- Testing/scoring schedule: DAy 1: application of first patch; Day 5 removal of patch and scoring; Day 21 application of second patch; Days 23/26/31 scoring
Results and discussion
- Results of examinations:
- OPP did not cause primary irritation when tested as a 5% solution in sesame oil nor did it cause any sensitisation.
Applicant's summary and conclusion
- Conclusions:
- not sensitising
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