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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study well documented

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997
Reference Type:
secondary source
Title:
O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
Author:
Bomhard, E. M. et al.
Year:
2002
Bibliographic source:
Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
None
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
yes

Test animals

Species:
human
Sex:
male

Administration / exposure

Route of administration:
dermal
Vehicle:
other: 0.4 % solution in iso-propanol
Duration and frequency of treatment / exposure:
8 hour(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
100 µL of 0.4 % (w/v) OPP in isopropanol
No. of animals per sex per dose:
6 males

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes

Any other information on results incl. tables

OPP is rapidly absorbed via skin and excreted predominantly via urine.  The vast majority of absorbed material is excreted within the first 24 h  after application. The entire absorbed dose is recovered in excreta, thus  leaving no potential for systemic or dermal accumulation.  
The major metabolite identified in all urine samples analysed was the sulphate conjugate of OPP. This metabolite accounted for 68.33 % of the absorbed dose. Conjugation of OPP with glucuronic acid was less significant, accounting for only 3.46 % of the absorbed dose. Hydroxylation of the phenol or phenyl ring, followed by conjugation was shown to be significant, with the glucuronide conjugate of phenylhydroquinone (PHQ-Gluc) and 2, 4´ dihydroxy biphenyl-sulfate (2, 4´-DHB-Sulf) representing 14.34 % and 12.35 % of the absorbed dose, respectively. No sulphate conjugates of PHQ was observed in any of the urine samples analysed, contrary to metabolism of OPP in rat and mouse, in which comparable amounts of both PHQ-conjugates are found, independent from the applied dose.
Low levels of free OPP (0.5 % of absorbed dose) and the glucuronide conjugate (OPP-Gluc) were observed in the early time intervals. Free OPP was not observed in any of the analysed samples.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results