Biphenyl-2-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP, no guideline followed, but essentially compliant with acceptable standards

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Reference 2

Reference Type:

secondary source

Title:

O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment

Author:

Bomhard, E. M. et al.

Year:

2002

Bibliographic source:

Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

(only 1 h exposure, no individual animal data given, no data given on environmental conditions during exposure, only nominal concentration determined, no data on particle size distribution given, no necropsy performed)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Biphenyl-2-ol

EC Number:

201-993-5

EC Name:

Biphenyl-2-ol

Cas Number:

90-43-7

Molecular formula:

C12H10O

IUPAC Name:

[1,1'-biphenyl]-2-ol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Weight at study initiation: 170-190 g
- Housing: in Makrolon cages Type III

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

nose only

Vehicle:

other: ethanol/PEG 400

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation apparatus
- System of generating particulates/aerosols: The dissolved test item was dynamically sprayed into the inhalation chamber as an aerosol

Analytical verification of test atmosphere concentrations:

yes

Remarks:

The test item was sprayed along with oil red and adsorbed on cotton wool. From this, oil red was eluted quantitatively with xylene and recorded photometrically at 225 nm. The percentage of oil red/L air corresponded to the percentage of test material.

Duration of exposure:

1 h

Concentrations:

228, 447 or 949 mg/m³ air

No. of animals per sex per dose:

20 males

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 949 mg/m³ air

Based on:

test mat.

Exp. duration:

1 h

Remarks on result:

other: No clinical symptoms observed

Mortality:

There was no mortality observed throughout the study period.

Clinical signs:

other: There were no clinical signs observed throughout the study period.

Body weight:

There was no effect on body weight development observed throughout the study period.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

DSD: not classified
CLP: not classified