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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, no guideline followed, but essentially compliant with acceptable standards

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1977
Report Date:
1977
Reference Type:
secondary source
Title:
O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
Author:
Bomhard, E. M. et al.
Year:
2002
Bibliographic source:
Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
(only 1 h exposure, no individual animal data given, no data given on environmental conditions during exposure, only nominal concentration determined, no data on particle size distribution given, no necropsy performed)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
aerosol dispenser: not specified
Remarks:
migrated information: aerosol
Details on test material:
- Name of test material (as cited in study report): Preventol O, (2-Phenylphenol)
- Physical state: solid (flakes, almost colour and odourless)
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Weight at study initiation: 170-190 g
- Housing: in Makrolon cages Type III

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other: ethanol/PEG 400
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic inhalation apparatus
- System of generating particulates/aerosols: The dissolved test item was dynamically sprayed into the inhalation chamber as an aerosol
Analytical verification of test atmosphere concentrations:
yes
Remarks:
The test item was sprayed along with oil red and adsorbed on cotton wool. From this, oil red was eluted quantitatively with xylene and recorded photometrically at 225 nm. The percentage of oil red/L air corresponded to the percentage of test material.
Duration of exposure:
1 h
Concentrations:
228, 447 or 949 mg/m³ air
No. of animals per sex per dose:
20 males
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 949 mg/m³ air
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: No clinical symptoms observed
Mortality:
There was no mortality observed throughout the study period.
Clinical signs:
other: There were no clinical signs observed throughout the study period.
Body weight:
There was no effect on body weight development observed throughout the study period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
DSD: not classified
CLP: not classified