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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1981

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl-2-ol
EC Number:
201-993-5
EC Name:
Biphenyl-2-ol
Cas Number:
90-43-7
Molecular formula:
C12H10O
IUPAC Name:
[1,1'-biphenyl]-2-ol
Details on test material:
Case 1: OPP (ortho-Phenylphenol) in germicidal cleaning agent in combination with a hand cream
Case 2: Coolant with OPP

Results and discussion

Any other information on results incl. tables

Case 1:	Patch testing with the cream and OPP in 0.5% and 1%  concentrations showed strong positive reactions at 72 h. In the hospital  laboratory where the individual worked, a germicidal agent containing OPP  was used, but he was careful to avoid contact with it and experienced no  further dermatitis
Case 2: Patch testing and "provocative use test" revealed a positive reaction.
When a new coolant with double the concentration of OPP was introduced into the plant, the patient became so severely affected that he had to leave work entirely.

Applicant's summary and conclusion

Conclusions:
OPP is a skin irritant