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Toxicity to birds

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Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
GLP compliance:
yes
Test organisms (species):
Anas platyrhynchos
Duration (if not single dose):
14 d
Dose descriptor:
NOEC
Effect level:
2 250 mg/kg bw
Basis for effect:
other: all endpoints
Duration (if not single dose):
14 d
Dose descriptor:
LC50
Effect level:
> 2 250 mg/kg bw
Basis for effect:
other: all endpoints
Validity criteria fulfilled:
yes
Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
EPA OPP 71-2 (Avian Dietary Toxicity Test)
GLP compliance:
yes
Test organisms (species):
Colinus virginianus
Limit test:
no
Reference substance (positive control):
no
Duration (if not single dose):
5 d
Dose descriptor:
NOEC
Effect level:
5 620 mg/kg bw
Basis for effect:
other: all enpoints
Duration (if not single dose):
5 d
Dose descriptor:
LC50
Effect level:
> 5 620 mg/kg bw
Basis for effect:
other: all enpoints
Validity criteria fulfilled:
yes
Endpoint:
short-term toxicity to birds: dietary toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
EPA OPP 71-2 (Avian Dietary Toxicity Test)
GLP compliance:
yes
Test organisms (species):
Anas platyrhynchos
Duration (if not single dose):
5 d
Dose descriptor:
NOEC
Effect level:
3 160 mg/kg bw
Basis for effect:
body weight
Duration (if not single dose):
5 d
Dose descriptor:
LC50
Effect level:
> 5 620 mg/kg bw
Basis for effect:
body weight

Description of key information

OPP can be considered as non-toxic to birds

Key value for chemical safety assessment

Additional information

Toxicity to birds is not a standard requirement according to Regulation (EC) No. 1907/2006, Annex VII-IX. OPP (CAS-No. 90-43-7) is readily biodegradable with a low potential for bioaccumulation in biota (see IUCLID section 5.3) and therefore, according to the Guidance on information requirements and chemical safety assessment, Chapter R.7c, secondary poisoning is unlikely to occur (ECHA, 2008). However, additional data obtained from three tests according to US-EPA guideline 71-1 and 71-2 are available.

The results of the study carried out according to US-EPA guideline 71-1 indicate that OPP was not harmful to adult Anas platyrhynchos up to the highest tested dosage of 2250 mg a. i. /kg bw, i. e. The acute oral LD50 was determined to be > 2250 mg a. i. /kg bw (Grimes, 1986a).

In the two studies performed according to US-EPA guideline 71-2, subacute effects on Anas platyrhynchos and Colinus virginianus were investigated. No mortalities or abnormal behaviour were observed for Anas platyrhynchos (Grimes, 1986b). The LC50 value of OPP was determined to be greater than the highest concentration of 5620 mg a. i. /kg diet for Colinus virginianus, and for Anas platyrhynchos the NOEC was 3160 mg a. i. /kg diet based upon a slight reduction in body weight gain at 5620 mg a. i. /kg diet (Grimes, 1986c).

Based on the results, OPP is not expected to have effects on birds.