Registration Dossier
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EC number: 201-993-5 | CAS number: 90-43-7
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
- GLP compliance:
- yes
- Test organisms (species):
- Anas platyrhynchos
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- NOEC
- Effect level:
- 2 250 mg/kg bw
- Basis for effect:
- other: all endpoints
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- LC50
- Effect level:
- > 2 250 mg/kg bw
- Basis for effect:
- other: all endpoints
- Validity criteria fulfilled:
- yes
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-2 (Avian Dietary Toxicity Test)
- GLP compliance:
- yes
- Test organisms (species):
- Colinus virginianus
- Limit test:
- no
- Reference substance (positive control):
- no
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- NOEC
- Effect level:
- 5 620 mg/kg bw
- Basis for effect:
- other: all enpoints
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 mg/kg bw
- Basis for effect:
- other: all enpoints
- Validity criteria fulfilled:
- yes
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-2 (Avian Dietary Toxicity Test)
- GLP compliance:
- yes
- Test organisms (species):
- Anas platyrhynchos
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- NOEC
- Effect level:
- 3 160 mg/kg bw
- Basis for effect:
- body weight
- Duration (if not single dose):
- 5 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 mg/kg bw
- Basis for effect:
- body weight
Referenceopen allclose all
Description of key information
OPP can be considered as non-toxic to birds
Key value for chemical safety assessment
Additional information
Toxicity to birds is not a standard requirement according to Regulation (EC) No. 1907/2006, Annex VII-IX. OPP (CAS-No. 90-43-7) is readily biodegradable with a low potential for bioaccumulation in biota (see IUCLID section 5.3) and therefore, according to the Guidance on information requirements and chemical safety assessment, Chapter R.7c, secondary poisoning is unlikely to occur (ECHA, 2008). However, additional data obtained from three tests according to US-EPA guideline 71-1 and 71-2 are available.
The results of the study carried out according to US-EPA guideline 71-1 indicate that OPP was not harmful to adult Anas platyrhynchos up to the highest tested dosage of 2250 mg a. i. /kg bw, i. e. The acute oral LD50 was determined to be > 2250 mg a. i. /kg bw (Grimes, 1986a).
In the two studies performed according to US-EPA guideline 71-2, subacute effects on Anas platyrhynchos and Colinus virginianus were investigated. No mortalities or abnormal behaviour were observed for Anas platyrhynchos (Grimes, 1986b). The LC50 value of OPP was determined to be greater than the highest concentration of 5620 mg a. i. /kg diet for Colinus virginianus, and for Anas platyrhynchos the NOEC was 3160 mg a. i. /kg diet based upon a slight reduction in body weight gain at 5620 mg a. i. /kg diet (Grimes, 1986c).
Based on the results, OPP is not expected to have effects on birds.
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