Registration Dossier
Registration Dossier
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EC number: 201-993-5 | CAS number: 90-43-7
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes
- Dissociating properties:
- yes
- pKa:
- 9.5
- Temp.:
- 20 °C
- Remarks on result:
- other: Acid-base constant: pKa = 9.5 ± 0.1
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study, solvent used, therefore results are not so accurate
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes
- pKa:
- 11.4
Referenceopen allclose all
Description of key information
pKa: 9.5 at 20 °C.
Key value for chemical safety assessment
- pKa at 20°C:
- 9.5
Additional information
A pKa value of 9.5 at 20°C was determined during tests according to OECD Guideline 112. A pKa value of 11.4 was determined in a different study during tests according to OECD Guideline 112. The difference between the two measured values could be attributed to the use of solvent in the second study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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