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Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
- pH: 4, 7, 9
- Type of buffer: phthalate buffer, phosphate buffer, borate buffer
Details on test conditions:
- Preparation of test medium: 0.3224 g o-phenylphenol were dissolved in 100 mL acetonitrile. Volumes of 100 mL buffer with 1 mL application solution (test substance in acetonitrile) were prepared for each pH level achieving a concentration of about 31.89 mg o-phenylphenol /L.


Duration:
5 d
Temp.:
50 °C
Initial conc. measured:
31.89 mg/L
Number of replicates:
One vessel was investigated at each sampling time for each temperature and each pH level
Transformation products:
no
pH:
4
Temp.:
50 °C
Remarks on result:
other: < 10% degradation after 5 days
pH:
7
Temp.:
50 °C
Remarks on result:
other: < 10% degradation after 5 days
pH:
9
Temp.:
50 °C
Remarks on result:
other: < 10% degradation after 5 days
Conclusions:
According to OECD Guideline No. 111 the chemical is considered hydrolytically stable and no additional testing is required.

Description of key information

Hydrolysis is not relevant in regard to abiotic degradation in the environment (DT50 > 1 yr).

Key value for chemical safety assessment

Additional information

The hydrolysis of OPP (CAS-No. 90-43-7) was studied in sterile aqueous buffered solutions at pH 4 (phthalate buffer), pH 7 (phosphate buffer) and pH 9 (borate buffer) according to OECD guideline 111. The concentrations of OPP were measured via HPLC-UV. In the preliminary test at 50 °C, a percentage of OPP of less than 10% was hydrolysed during 5 days. According to OECD guideline 111, the test substance is considered to be hydrolytically stable and no further testing is required (Reusche, 1991). This result corresponds to a half-life of far more than one year.