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EC number: 201-993-5 | CAS number: 90-43-7
Toxicological information
Acute Toxicity: dermal
Currently viewing:
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Nov 1990 - 11 Dec 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
- Reference Type:
- secondary source
- Title:
- O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
- Author:
- Bomhard, E. M. et al.
- Year:
- 2 002
- Bibliographic source:
- Crit. Rev. Toxicol. 32(6):551-626
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EEC (Gazette of the European Community, No. L 251, p. 103) (1984)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Biphenyl-2-ol
- EC Number:
- 201-993-5
- EC Name:
- Biphenyl-2-ol
- Cas Number:
- 90-43-7
- Molecular formula:
- C12H10O
- IUPAC Name:
- [1,1'-biphenyl]-2-ol
- Test material form:
- solid: crystalline
- Details on test material:
- Batch No.: Pa. 18
Constituent 1
- Specific details on test material used for the study:
- - Stability under test conditions: Analytic investigations on the stability of the test compound in the vehicle were not carried out for logistic reasons and since there was only a short period of time between preparation and application.
- Storage condition of test material: at room temperature, dry
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: young adult
- Weight at study initiation:229 g (males) and 191 g (females)
- Fasting period before study: no
- Housing: individually in Makrolon Type-II cages on low-dust wood granules (Ssniff, Soest/Westphalia, Germany)
- Diet: fixed formula standard diet Altromin 1324 Pellets (Altrmin GmbH and Co KG, Lage, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2
- Humidity (%): 50±10
- Air changes (per hr): approximately 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: test substance was worked up into a paste using several drops of Cremophor E (non-ionic organic emulgator)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: approximately 10% of the body surface
- Type of wrap if used: skin plaster (Fermoflexband, Beiersdorf AG, Germany)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with luke-warm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Constant volume or concentration used: no (application volume for each animal was based on its body weight just prior to application)
- For solids, paste formed: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): several drops - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw (Limit test)
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of administration, twice daily thereafter (once daily on weekends and holidays)
- Frequency of weighing: directly before administration (day 1), after 1 week and at study termination
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred throughout the study period.
- Clinical signs:
- other: other: There were no test material related signs of systemic toxicity noted throughout the study period. As a local skin change slight reddening was observed in males and females on the day after application, this redness turned to incrustation on day 5
- Gross pathology:
- There were no test material related changes noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DSD: not classified
CLP: not classified
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