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Long-term toxicity to fish

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Description of key information

Overall NOEC (21 d) for Pimephales promelas = 0.036 mg a.i./L (measured)

Key value for chemical safety assessment

Additional information

The prolonged toxicity of OPP (CAS-No. 90-43-7) to fathead minnow (Pimephales promelas) was tested in a reproductive performance test by Caunter & Williams (2002). The test was carried out based on the method described by Harries et al. (2000). This publication is a discussion document for a future OECD Guideline.

In the test chemical exposures were conducted for 21 days, while measures of fecundity were assessed daily. Viability of resultant embryos was assessed in animals held in the same treatment regime to which the adults were exposed. A suite of histological and biological endpoints, that potentially are directly reflective of effects associated with endocrine disrupting chemicals, was also evaluated.

The results of the study show that OPP does not indicate any adverse effects on reproductive parameters of pair-breeding fathead minnows up to a nominal test concentration of 50 µg a.i./L. With regard to the induction of the biomarker vitellogenin as an early indicator of possible endocrine modulation, no substance-related effects were noted compared to the positive control 17α-ethynylestradiol.

Based on mean measured concentration the overall NOEC (21 d) was determined as 0.036 mg a.i./L and the overall LOEC (21 d) as 0.293 mg a.i./L.

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