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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to accepted scientific standards
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996
Reference Type:
secondary source
Title:
O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment
Author:
Bomhard, E. M. et al.
Year:
2002
Bibliographic source:
Crit. Rev. Toxicol. 32(6):551-626

Materials and methods

Principles of method if other than guideline:
Absorption through skin and subsequent metabolism and excretion was investigated in human volunteers
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl-2-ol
EC Number:
201-993-5
EC Name:
Biphenyl-2-ol
Cas Number:
90-43-7
Molecular formula:
C12H10O
IUPAC Name:
[1,1'-biphenyl]-2-ol
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
human
Sex:
male

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: 2-propanol
Duration of exposure:
8 hours
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
0.006 mg OPP/kg bw, ~17 µg/cm²
Parameter:
percentage
Absorption:
43.15 %
Remarks on result:
other: 8 h
Conversion factor human vs. animal skin:
not applicable

Applicant's summary and conclusion