Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-557-4
CAS number: 84-74-2
DBP is not considered to be carcinogenic to humans.
adequate long-term toxicity and/or carcinogenicity studies in animals or
man are available.
esters are known to induce peroxisomal proliferation in the liver of
mice and rats. In general
the longer chain dialkylphthalates are more potent for the induction of
than the shorter chain ones and branched chain phthalates seemed more
potent than straight.
Many peroxisome proliferators have been shown to induce hepatocellular
tumours when administered
at high dose-levels for long periods to mice and rats despite being
mechanisms of induction of carcinogenicity by peroxisome proliferators
may be complex but
are considered to have a threshold. A variety of independent studies
have shown that there are
marked species differences in the sensitivity to chemicals that cause
Rats and mice are extremely sensitive, hamsters show a less marked
guinea-pigs, primates and man are rather insensitive or non-responsive.
is not considered to be carcinogenic to humans when taking into account
that the mechanisms by which DBP and hypolipidaemic substances induce
peroxisome proliferation in rodents are not considered relevant to
humans, and the absence of evidence associating DBP exposure to
carcinogenic effects in humans.(2)
Union Risk Assessment Report dibutyl phthalate, Volume 29, p. 16 (2003)
B. G. Hansen, S.J. Munn, R. A/Ianou, F. Berthault, J. de Bruin, M.
Luotamo, C. Musset, S. Pakalin, G. Pellegrini, S. Scheen S. Vegro.
for Official Publications of the European Communities, ISBN 92—894—1276—3
Priority Existing Chemical Assessment Report
No. 36, Dibutyl phthalate, November 2013, ISBN 978-0-9874434-4-1, p.84
Australian Government, Department of Health
NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION
AND ASSESSMENT SCHEME
GPO Box 58, Sydney NSW 2001 AUSTRALIA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again