Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-557-4
CAS number: 84-74-2
In a GLP-compliant study by Greenough et al. (1981*), the inhalation
LC50 in rats was estimated to be ≥15.68 mg/L/4h. SD rats (5/sex/dose)
were exposed to 12.45, 15.68 and 16.27 mg DBP/L of air for four hours,
and observed for 14 days. Controls were air exposed. The respirable
fraction was 64.4 %, 56.9 %, and 59.9 %, respectively. A reduction in
respiratory rate was seen at 15.68 mg/L. Excessive grooming in surviving
animals led to persistent poor coat condition throughout the study.
Macroscopy of the lungs revealed the following anomalies: white foci in
all lobes in one male and one female rat at 15.68 mg/L, dark red regions
in two female rats at 12.45 mg/L, and one male and one female rat at
16.27 mg/L. 6.2.2 Skin,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again