Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Test animals

Species:
rat

Administration / exposure

Duration of exposure:
4 h

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
>= 15.68 mg/L air
Exp. duration:
14 d
Remarks on result:
other: Greenough et al. 1981
Clinical signs:
Excessive grooming in surviving animals led to persistent poor coat condition throughout the study. Macroscopy of the lungs revealed the following anomalies: white foci in all lobes in one male and one female rat at 15.68 mg/L, dark red regions in two female rats at 12.45 mg/L, and one male and one female rat at 16.27 mg/L.

Applicant's summary and conclusion

Executive summary:

In a GLP-compliant study by Greenough et al. (1981*), the inhalation LC50 in rats was estimated to be ≥15.68 mg/L/4h. SD rats (5/sex/dose) were exposed to 12.45, 15.68 and 16.27 mg DBP/L of air for four hours, and observed for 14 days. Controls were air exposed. The respirable fraction was 64.4 %, 56.9 %, and 59.9 %, respectively. A reduction in respiratory rate was seen at 15.68 mg/L. Excessive grooming in surviving animals led to persistent poor coat condition throughout the study. Macroscopy of the lungs revealed the following anomalies: white foci in all lobes in one male and one female rat at 15.68 mg/L, dark red regions in two female rats at 12.45 mg/L, and one male and one female rat at 16.27 mg/L. 6.2.2 Skin,