Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Dibutyl phthalate
  • IUPAC name: 1,2-dibutyl benzene-1,2-dicarboxylate
  • Other names
EC / List no.:
201-557-4
CAS no.:
84-74-2
Index number:
607-318-00-4
Molecular formula:
C16H22O4
SMILES:
CCCCOC(=O)C1=C(C=CC=C1)C(=O)OCCCC
InChI:
InChI=1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
11
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may damage the unborn child and is suspected of damaging fertility and is very toxic to aquatic life.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child and is toxic to aquatic life with long lasting effects.

Breakdown of all 939 C&L notifications submitted to ECHA

Aquatic Acute 1 H400 Harmonised Classification
Repr. 1B H360Df Harmonised Classification
Aquatic Chronic 2 H411
Repr. 2 H360
Aquatic Chronic 2 H410
Aquatic Chronic 1 H410
Aquatic Chronic 3 H412
Carc. 1A H350
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 8 active registrations under REACH, 2 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Substance of very high concern requiring authorisation before it is used (Annex XIV of REACH).
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: vehicles, machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines) and electrical batteries and accumulators. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), leather (e.g. gloves, shoes, purses, furniture) and metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: metal working fluids, washing & cleaning products and laboratory chemicals.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development. This substance is used for the manufacture of: fabricated metal products, machinery and vehicles, rubber products, plastic products and chemicals.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals, mixing in open batch processes, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release and formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following products: explosives and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals at dedicated facilities, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: laboratory chemicals, adsorbents, explosives and polymers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging and mining. This substance is used for the manufacture of: chemicals, machinery and vehicles, plastic products and fabricated metal products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, laboratory work, closed batch processing in synthesis or formulation, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, batch processing in synthesis or formulation with opportunity for exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, of substances in closed systems with minimal release and in the production of articles.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; obtain special instructions before use; use personal protective equipment as required.; avoid release to the environment.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention. Collect spillage.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • ExponentOR28, The Lenz Hornbeam Business Park HG28RE Harrogate Yorkshire United Kingdom
  • GRACE Catalyst AB, Industrivägen 44432 Stenungsund Sweden
  • Grace Catalysts & Materials, S.L.U., Carretera N-340, km 1.156 43006 Tarragona Spain
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • GRACE GmbH (OR1), In der Hollerhecke 1 67547 Worms Germany
  • INEOS Services Belgium NV (OR), Rue de Ransbeek 310 1120 Bruxelles Belgium

Other names

  • -
  • 1,2-Benzenedicarboxylic acid, dibutyl ester
  • 1,2-dibutyl benzene-1,2-dicarboxylate
  • benzene-1,2-dicarboxylic acid dibutyl ester
  • CAS 84-74-2
  • DBP
  • dibutyl benzene-1,2-dicarboxylate
  • DIBUTYL PHTHALATE
  • dibutyl phthalate; DBP
  • Dibutylphthalat
  • Dibutylphthalate
  • DBP
  • Dibutyl phthalate
  • Dibutyl phthalate (DBP)
  • DBP
  • Dibutyl phthalate
  • DNBP

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Compact (50%), Other (50%) [2]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 9 studies submitted
  • 3 studies processed
R Melting / freezing point
-69 - -35 °C [3]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-69 - -67.2 °C

Boiling point

Study results
  • 6 studies submitted
  • 4 studies processed
R Boiling point
340 °C @ 101.3 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
340 °C

Density

Study results
  • 6 studies submitted
  • 4 studies processed
R Density
1.049 g/cm³ @ 20 °C [1]
R Relative density
1.045 - 1.05 @ 20 °C [3]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.045 - 1.049

Vapour pressure

Study results
  • 10 studies submitted
  • 3 studies processed
R Vapour pressure
0.006 - 0.013 Pa @ 25 °C [3]

Type of Study provided
Studies with data
Key study 4
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0.01 - 970 Pa @ 20 - 25 °C

Partition coefficient

Study results
  • 8 studies submitted
  • 4 studies processed
R Log Pow
4.46 - 4.79 @ 25 - 30 °C and pH 5 - 8 [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
4.46 - 4.57 @ 20 - 30 °C

Water solubility

Study results
  • 8 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
10 - 11.4 mg/L @ 20 - 25 °C and pH 6.41 - 7 [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
10 - 11.4 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 6 studies submitted
  • 4 studies processed
R Flash point
157 - 186.5 °C @ 99.5 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
157 - 186.5 °C

Auto flammability

Study results
  • 7 studies submitted
  • 4 studies processed
R Autoflammability / self-ignition
390 - 403 °C @ 100 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
390 - 403 °C

Flammability

Study results
  • 9 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 6
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 4 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 3 studies processed
R dynamic viscosity (in mPa s)
20.3 [2]
R kinematic viscosity (in mm²/s)
18.8 [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
18.8 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
64.8 - 65.8 h @ 50 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 12 studies submitted
  • 3 studies processed
R BOD5*100/COD
63 mg O2/g test material [1]
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
7.01 days @ 25 °C
Half-life in freshwater sediment
71.04 h @ 25 °C

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
1.8 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
1

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Koc at 20°C
1 157 - 1 386

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
0.124 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.124 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 10 µg/L (2)
Intermittent releases (freshwater) 4.8 µg/L (1)
Marine water 1 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 220 µg/L (1)
Sediment (freshwater) 1.19 mg/kg sediment dw (1)
Sediment (marine water) 119 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 50 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 1.33 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 12 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 480 - 1 600 µg/L [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other 2 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
480 µg/L

Long–term toxicity to fish

Study results
  • 9 studies submitted
  • 1 study processed
P/RResults
NOEC (3.3 months) 100 - 190 µg/L [3]
LOEC (3.3 months) 190 - 400 µg/L [3]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 3
Weight of evidence
Other 2 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
100 µg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 20 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 3 - 2 990 µg/L [2]
LC50 (4 days) 500 - 6 290 µg/L [2]
EC10 (48 h) 3 µg/L [1]
NOEC (4 days) 260 - 2 350 µg/L [2]
NOEC (48 h) 1.7 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 10
Weight of evidence 1
Other 2 5
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
EC50 / LC50 for freshwater invertebrates
760 - 3 400 µg/L
EC50 / LC50 for marine invertebrates
500 - 800 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 11 studies submitted
  • 3 studies processed
P/RResults
NOEC (25 days) 100 µg/L [1]
NOEC (21 days) 158 µg/L [1]
NOEC (16 days) 560 µg/L [1]
LOEC (21 days) 811 µg/L [1]
LOEC (16 days) 1.8 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 1
Weight of evidence
Other 2 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
100 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 12 studies submitted
  • 1 study processed
P/RResults
EC50 (10 days) 750 µg/L [1]
NOEC (10 days) 390 µg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other 4 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
750 - 1 720 µg/L
EC10 or NOEC for freshwater algae
200 - 390 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 3 studies processed
P/RResults
EC50 (24 h) 2.2 mg/L [1]
NOEC (30 min) 10 mg/L [2]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 4
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
EC50 for microorganisms
2.2 mg/L
EC10 or NOEC for microorganisms
10 mg/L

Sediment toxicity

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
NOEC (56 days) 100 mg/kg sediment dw [2]
NOEC (35 days) 1 000 mg/kg sediment dw [1]
NOEC (26 days) 1 000 mg/kg sediment dw [1]
NOEC (10 days) 41.6 - 3 410 mg/kg sediment dw [5]
NOEC (10 days) 448 - 4 760 µg/L [6]

Type of Study provided
Studies with data
Key study 4 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater sediment
826 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
100 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
NOEC (14 days) 1 g/kg soil dw [1]
NOEC (7 days) 1 g/kg soil dw [1]
LC50 (14 days) 1 g/kg soil dw [1]
LC50 (7 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC10 (42 days) 500 - 10 000 µg/kg soil dw [2]
EC10 (21 days) 14 mg/kg soil dw [1]
LC10 (42 days) 11.3 mg/kg soil dw [1]
LC10 (21 days) 33 mg/kg soil dw [1]
EC50 (42 days) 10 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Short-term EC50 / LC50
10 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
500 µg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 10 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 20 g/kg soil dw [2]
EC10 (21 days) 200 mg/kg soil dw [2]
EC50 (21 days) 2 - 20 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 4 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Short-term EC50 / LC50
387 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
200 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (30 days) 472 µg/kg soil dw [1]
NOEC (15 days) 472 µg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 1 700 mg/kg diet [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 130 µg/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 2.84 mg/m³ repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 190 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 20 µg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 70 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 7 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 34 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 4 8
Supporting study 2
Weight of evidence 1
Other 4 15
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 5 %

Acute toxicity

Study results
oral
  • 8 studies submitted
  • 3 studies processed
P/RResults
LD50 6 279 mg/kg bw (rat) [3]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 15.68 mg/L air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 8
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 6 279 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 34 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 152 mg/kg bw/day [6]
LOAEL (rat): 752 mg/kg bw/day [6]
NOEL (mouse): 5 000 ppm [1]
LOEL (rat): 5 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study 8
Supporting study 1
Weight of evidence
Other 25
Data waiving
no waivers
Study data: inhalation
  • 7 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 509 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 2 3
Data waiving
no waivers
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 19 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4 1
Supporting study 6 1
Weight of evidence
Other 8
Data waiving
no waivers
Study data: in vivo
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 17
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4 1
Supporting study
Weight of evidence
Other 8
Data waiving
no waivers
Study data: developmental
  • 55 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 7
Supporting study 2 1
Weight of evidence
Other 45
Data waiving
no waivers
Study data: other studies
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 14
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant