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EC number: 201-557-4
CAS number: 84-74-2
Di-n-butylphthalate was rapidly converted by rainbow traut liver
microsomes to unextractable compound present in the aqueous phase (Table
16). Approximately 40% of the radiolabeled compound was converted within
15 min, and 60% within 1 hr. Irreversible protein binding occurred
throughout the 2 hr incubation with 14C labeled di-n-butylphthalate.
Approximately 9% of the radiolabeled compound was bound to the trout
liver microsomes during a 2 hr incubation with 7% of the total bound in
the first 15 min of incubation.
Radiolabeled di-n-butylphthalate was converted more slowly by Daphnia
PMS during a 1 hr incubation than by trout liver microsomes. Only about
10% of the radiolabeled compound was converted (Table 16) to water
soluble hexane unextractable compounds. Less than 1% of the
di-n-butylphthalate was irreversibly bound to protein.
di-n-butylphthalate was incubated with a protein substrate and NADPH
generating system to determine metabolism and irreversible protein
binding of di-n-butylphthalate in rainbow traut liver microsomes and
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