Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Study type:
study with volunteers

Method

Route of exposure:
dermal
Reason of exposure:
intentional

Results and discussion

Any other information on results incl. tables

Results demonstrated increases in MBP in serum and urine within a few hours of application. An average of 1.82 % (range 0.11–5.94 %) of the applied DBP dose was recovered in urine as MBP during the treatment week.

Applicant's summary and conclusion

Executive summary:

The study (Janjua et al. 2007 ND, 2008 ND) suggests that DBP absorption via the dermal route in humans under conditions of usual cosmetic application is low.