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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a short summary in English, including many tables and figures, is available; the complete study discription is in Japanese.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
6h/day for 6 months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5, 50 mg/m³
Basis:

Control animals:
yes

Results and discussion

Results of examinations

Body weight and weight changes:
effects observed, treatment-related
Haematological findings:
effects observed, treatment-related
Clinical biochemistry findings:
effects observed, treatment-related
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The rats in the high concentration group showed a smaller body weight gain, and greater brain and lung weights when compared to the control group. The former also showed abnormal serum findings such as high urea nitrogen, low cholesterol, and for some, high transaminase activity. The rats in the low concentration group showed similar findings, but at comparatively low levels. An increased percentage of neutrophiles was observed in both groups.

Applicant's summary and conclusion

Conclusions:
It was concluded that prolonged exposure to DBP at concentrations of 50mg/m³ produces adverse effects in rats, but that even low level is harmful.
Executive summary:

This is an English summary of a Japanese inhalation experiment on rats. A detailed Japanese study report is attached as full study report.