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EC number: 201-557-4
CAS number: 84-74-2
All invertebrates continuously exposed to 14C-di-n-butyl phthalate
showed an initial rapid uptake and accumulation of radioactive residues
several hundred times greater than the concentration in water (Table 2).
With the exception of some species of invertebrates, the accumulation of
di-2-ethylhexyl phthalate was greater than that of di-n-butyl phthalate.
Di-2-ethylhexyl phthalate residues were
accumulated and stored by scuds during a 14-day exposure at levels 3600
times greater than the 0.1 ,g/l. concentrations in the surrounding
water, whereas scuds exposed for 14 days to 0.1 pg/l. of di-n-butyl
phthalate accumulated total body concentrations 1400 times the phthalate
concentrations in water. Phthalic acid esters were accumulated in
invertebrates to a similar degree as that found with the same species of
invertebrates exposed to organochlorine insecticides.
Waterfleas (Daphnia magna) were exposed to 0.1 mg/l. of di-n-butyl
phthalate for 7 days and then transferred to fresh flowing
water to determine the time required for elimination of phthalate
residues. After 3 days, 50% of the total radioactivity remained;
25% of the activity was still present after 7 days in fresh water.
Invertebrate metabolism of phthalic acid esters was not determined, and
the loss in radioactive residues may have been due to metabolism and/or
excretion of the parent compound.
This is part of a study with DBP and di-2-ethylhexyl phthalate relating
to acute toxicity, reproduction and accumulation & excretion. Only the
last examinations (accumulation & excretion) concerning DBP are
Based on a log Pow of 4.11 (Leyder & Boulanger 1983) a bioconcentration
factor of 780 was calculated (Bysshe 1982).
In 1974 the Environmental Agency Japan conducted studies with DIBP on
fish and with water. Water samples showed DIBP levels of 0.16 to 1.2
micrograms per litre. Fish samples showed 150 to 470 micrograms per
kilogram. Neither the species nor the applied concentration of DIBP is
mentioned. According to the stated values bioaccumulation factors of 125
to 2937 were determined. (Environmental Agency Japan 1985)
Source: Beratergremium für umweltrelevante Altstoffe (BUA) der
Gesellschaft deutscher Chemiker: Diisobutylphthalat, BUA-Stoffbericht
201; Dr . H. Behret, Gesellschaft deutscher Chemiker, Postfach 900440,
60444 Frankfurt am Main, Germany; p. 50; ISBN 3-7776-0788-6; S. Hirzel
Verlag, Stuttgart 1997
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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