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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Test animals

Species:
rabbit

Results and discussion

Any other information on results incl. tables

A study in rabbits with undiluted DBP (OECD Guideline 404) revealed slight erythema in 2 out of 3 animals immediately after exposure and after 24 hours. No oedema was seen. Erythema disappeared 48 hours after exposure. DBP was not considered a skin irritant (BASF 1990a*).

Greenough et al. (1981*) reported mild reactions 24 hours after 0.5 mL of undiluted Vestinol C (DBP trade name) was applied to intact and abraded rabbit skins. The positive control was reported as 10 % laurylsulphate. No reaction was observed after 72 hours at any treatment site. The irritation index was calculated as 0.54/8.

A study cited in an NTP-CERHR report on DBP (CERHR 2003) reported minor irritation in rabbit dermal occlusion studies at 520 mg/kg bw/d.

Applicant's summary and conclusion

Conclusions:
These studies suggest that DBP causes minimal skin irritation in rabbits.
Executive summary:

Sligth skin irritation was reported, which dissappeared after 48h (study 1) or 72h (study 2).