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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

skin irritation: in vivo
Adequacy of study:
other information

Data source

Reference Type:

Materials and methods

Test guideline
according to guideline
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Test animals


Results and discussion

Any other information on results incl. tables

A study in rabbits with undiluted DBP (OECD Guideline 404) revealed slight erythema in 2 out of 3 animals immediately after exposure and after 24 hours. No oedema was seen. Erythema disappeared 48 hours after exposure. DBP was not considered a skin irritant (BASF 1990a*).

Greenough et al. (1981*) reported mild reactions 24 hours after 0.5 mL of undiluted Vestinol C (DBP trade name) was applied to intact and abraded rabbit skins. The positive control was reported as 10 % laurylsulphate. No reaction was observed after 72 hours at any treatment site. The irritation index was calculated as 0.54/8.

A study cited in an NTP-CERHR report on DBP (CERHR 2003) reported minor irritation in rabbit dermal occlusion studies at 520 mg/kg bw/d.

Applicant's summary and conclusion

These studies suggest that DBP causes minimal skin irritation in rabbits.
Executive summary:

Sligth skin irritation was reported, which dissappeared after 48h (study 1) or 72h (study 2).