Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Test animals / tissue source

Species:
rabbit

Results and discussion

Any other information on results incl. tables

In a study in rabbits with undiluted DBP (OECD Guideline 405), prominent conjunctival redness was observed after one hour and 24 hours in all animals, which reduced in severity after 48 hours and was completely reversed by 72 hours. DBP was not considered an eye irritant (BASF, 1990b*).

Undiluted 0.1 mL of Vestinol C (trade name of DBP) was applied to rabbit eyes (3/sex), which were not rinsed post administration. After one hour, three out of six animals showed mild redness and the balance (three animals) exhibited extremely mild redness. After 24 hours, very mild redness was observed in two out of six animals. Iris or corneal effects were not observed. The irritation index was calculated as 0.11/110. DBP was not considered an eye irritant (Greenough et al. 1981*).

Applicant's summary and conclusion

Conclusions:
These studies suggest that DBP causes minimal eye irritation in rabbits.
Executive summary:

Slight reversive eye irritation was observed in both studies.