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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

eye irritation: in vivo
Adequacy of study:
other information

Data source

Reference Type:

Materials and methods

Test guideline
according to guideline
OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Test animals / tissue source


Results and discussion

Any other information on results incl. tables

In a study in rabbits with undiluted DBP (OECD Guideline 405), prominent conjunctival redness was observed after one hour and 24 hours in all animals, which reduced in severity after 48 hours and was completely reversed by 72 hours. DBP was not considered an eye irritant (BASF, 1990b*).

Undiluted 0.1 mL of Vestinol C (trade name of DBP) was applied to rabbit eyes (3/sex), which were not rinsed post administration. After one hour, three out of six animals showed mild redness and the balance (three animals) exhibited extremely mild redness. After 24 hours, very mild redness was observed in two out of six animals. Iris or corneal effects were not observed. The irritation index was calculated as 0.11/110. DBP was not considered an eye irritant (Greenough et al. 1981*).

Applicant's summary and conclusion

These studies suggest that DBP causes minimal eye irritation in rabbits.
Executive summary:

Slight reversive eye irritation was observed in both studies.