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EC number: 201-557-4
CAS number: 84-74-2
The CO2 evolution data, estimated rate constants and halflife, and
percentages of primary degradation for the PAEs and glucose tested in
sets 1 through 4 are presented in Table 1. It was originally intended to
run all of the PAEs in three sets; however, both of the blank units in
set 3 developed leaks to the atmosphere, which resulted in high levels
of BaCO3 precipitation. As a result, a fourth set was run in which CO2
evolution data were collected, as in the previous sets, but in which
specific PAE analysis was conducted only at the end of the test on the
contents of the triplicate CO2 evolution flasks.
In general, all of the PAEs were biodegraded rapidly as measured by loss
of the parent molecule (primary biodegradation) and percentage of CO2
evolution (ultimate biodegradation). The primary biodegradation at 28
days was >99%, except for DBP, BBP, and DTDP, which were 68 to >99%, 59
to 89%, and >50%, respectively. Similar conclusions could be reached
from the ultimate biodegradation data. All of the PAEs tested with
pQoled acclimated inoculum had >50% theoretical CO2 evolution at day 28
with the exception of BBP and DTDP, which were 43 and 37%, respectively.
However, BBP and DTDP were still degrading at day 28. The 95% confidence
limits indicate that many of the differences between the mean ultimate
biodegradation and rate constant values are not statistically
Variation in CO2 evolution values among the triplicates or duplicates
for each PAE and glucose in the sets can be examined by expressing the
standard deviation as a percentage of the mean values obtained from the
individual runs in a set. At day 28, the standard deviations of CO2
evolution data ranged between +/-2 and +/-37% of the respective means.
At day 28, the mean and median of the standard deviations were ±12 and
±5%, respectively. The ratio between the highest and lowest individual
CO2 evolution value among duplicates or triplicates on day 28 ranged
between 1.0 and 2.1 and
averaged 1.3. This indicates that individual values for a chemical
varied by no more than about twofold. The rate constant data were more
variable. The range, mean, and median of the standard deviations
(expressed as a percentage of the mean) were 2 to 57, 21, and 14.5%,
respectively. The ratio between the highest and lowest individual rate
constant amohg duplicates or triplicates ranged between 1.0 and 2.9 and
averaged 1.6, indicating that the individual rate constants for a
chemical varied about twofold on the average. All of the individual CO2
and rate constant values for a chemical in a set were within two
standard deviations of the set mean calculated for that chemical,
indicating that outlying data points were absent.
An acclimated shake flask CO2 evolution test was used to study the
biodegradability of 14 commercial phthalate esters that are commonly
used as plasticizers. Both CO2 evolution (ultimate biodegradation) and
loss of parent phthalate esters (primary biodegradation) were measured.
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