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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Test animals

Species:
rabbit

Administration / exposure

Duration of treatment / exposure:
90 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5, 1.0, 2.0, 4.0 mL/kg bw/d
Basis:

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Slight irritation and dermatitis were reported without information on the dose level at which it was observed. Slight renal damage was reported at 4.0 mL/kg bw/d.

Applicant's summary and conclusion

Conclusions:
Slight irritation and dermatitis were reported without information on the dose level at which it was observed. Slight renal damage was reported at 4.0 mL/kg bw/d.
Executive summary:

In this poorly documented study (Lehmann 1955) on rabbit slight skin irritation and dematistis were reported. Also slight renal damage was reported at 4.0 mL/kg bw/d.