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EC number: 201-557-4
CAS number: 84-74-2
As far as studies are available DBP is not expected to have significant acute toxicity in humans.
of the acute toxicity studies have been performed according to current
available data DBP is slightly toxic if swallowed (LD50 rat is≥6,300
mg/kg bw), slightly to moderately
toxic by inhalation (LC50 rat≥15.68
mg/L) and slightly toxic in contact with the skin (LD50
dermal rabbit >20,000 mg/kg bw). (1)
Given the low toxicity observed in the acute
oral, inhalation, and dermal studies, the effects observed in the
irritation and sensitisation studies and the anticipated occupational
exposure levels it is concluded that DBP is of no concern for workers
with respect to acute effects, irritation, and skin sensitisation. There
are no data available on the possible respiratory sensitisation.(2)
DBP has low acute oral, dermal and
inhalation toxicity in rodents with LD50s above 4000 mg/kg bw for oral
and above 20,000 mg/kg bw for dermal exposure. LC50 for inhalation
exposure in rats is ≥15.68 mg/L/4h. Intravenous and intraperitoneal
administration of DBP results in higher acute toxicity than oral or
dermal administration. The lowest LD50 for intravenous exposure in mice
is 720 mg/kg/bw.
One case report of acute poisoning in
humans, due to accidental ingestion of 10 g DBP, showed that the
symptoms of the poisoning were completely reversible by 14 days.
Overall, DBP is not expected to have
significant acute toxicity in humans. (3)
Union Risk Assessment Report dibutyl phthalate, Volume 29, p. 15 (2003)
B. G. Hansen, S.J. Munn, R. A/Ianou, F. Berthault, J. de Bruin, M.
Luotamo, C. Musset, S. Pakalin, G. Pellegrini, S. Scheen S. Vegro.
for Official Publications of the European Communities, ISBN
Union Risk Assessment Report dibutyl phthalate, Volume 29, p. 17 (2003)
for Official Publications of the European Communities, ISBN 92—894—1276—3
Existing Chemical Assessment Report No. 36, Dibutyl phthalate, November
2013, ISBN 978-0-9874434-4-1, p.82
Government, Department of Health
INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME
Box 58, Sydney NSW 2001 AUSTRALIA www.nicnas.gov.au
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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