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EC number: 202-163-5
CAS number: 92-52-4
Tumors in male rats dosed with 4500 ppm biphenyl were induced in high
association with calculus formation and hematuria, together with
pre-neoplastic, regenerative lesions in the urinary system.
The sustained mechanical damage caused by the bladder calculi plays an
important role in tumorigenesis. The physical characteristics of the
bladder calculi such as size and shape can be considered to affect the
degree and/or frequency of pre-neoplastic and neoplastic lesions
occurring in response to mechanical damage to the bladder epithelium
caused by calculi.
The authors indicated that a sex-difference in the metabolic pathways of
biphenyl plays an important role in the formation of bladder calculi and
the development of bladder tumors.
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