Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-163-5
CAS number: 92-52-4
Tumors in male rats dosed with 4500 ppm biphenyl were induced in high
association with calculus formation and hematuria, together with
pre-neoplastic, regenerative lesions in the urinary system.
The sustained mechanical damage caused by the bladder calculi plays an
important role in tumorigenesis. The physical characteristics of the
bladder calculi such as size and shape can be considered to affect the
degree and/or frequency of pre-neoplastic and neoplastic lesions
occurring in response to mechanical damage to the bladder epithelium
caused by calculi.
The authors indicated that a sex-difference in the metabolic pathways of
biphenyl plays an important role in the formation of bladder calculi and
the development of bladder tumors.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ez a weboldal cookie-kat használ a legjobb felhasználói élmény biztosítása érdekében.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again