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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study was conducted prior to existence of guidelines and GLP and the report does not contain sufficient information to permit a meaningful evaluation of study results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949
Report Date:
1949

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
Study conducted prior to GLP
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Diphenyl
- Physical state: not specified in the report
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: not specified in the report
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
Saturated vapor at room temperature (prepared by aerating a column packed with diphenyl and glass beads) and a mist produced by aerating the compund while heated to 170 °C in a bath of silicone.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 8 h
Concentrations:
no data
No. of animals per sex per dose:
6 rats
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

8 hours exposure to diphenyl vapor at room temperature was not lethal to rats. These animals gained weight well in the 14 day observation period.

Similarly a group of 6 rats survived at 8 hour exposure to a mist produced by aerating the diphenyl while it was heated at 170°C.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the study, 8 hours of exposure to diphenyl (substantially saturated vapor at room temperature and mists generated at 170 °C) were not considered to be lethal.