Registration Dossier
Registration Dossier
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EC number: 202-163-5 | CAS number: 92-52-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to existence of guidelines and GLP and the report does not contain sufficient information to permit a meaningful evaluation of study results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 949
- Report date:
- 1949
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Remarks:
- Study conducted prior to GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- Biphenyl
- EC Number:
- 202-163-5
- EC Name:
- Biphenyl
- Cas Number:
- 92-52-4
- Molecular formula:
- C12H10
- IUPAC Name:
- 1,1'-biphenyl
- Details on test material:
- - Name of test material (as cited in study report): Diphenyl
- Physical state: not specified in the report
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: not specified in the report
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Saturated vapor at room temperature (prepared by aerating a column packed with diphenyl and glass beads) and a mist produced by aerating the compund while heated to 170 °C in a bath of silicone.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 8 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- 6 rats
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
8 hours exposure to diphenyl vapor at room temperature was not lethal to rats. These animals gained weight well in the 14 day observation period.
Similarly a group of 6 rats survived at 8 hour exposure to a mist produced by aerating the diphenyl while it was heated at 170°C.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, 8 hours of exposure to diphenyl (substantially saturated vapor at room temperature and mists generated at 170 °C) were not considered to be lethal.
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