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EC number: 202-163-5
CAS number: 92-52-4
The Key Study of Takahashi and Blanchard (1974) provides a highly conservative representation of bioaccumulation potential for biphenyl, as the fish BCF value of 1,900 L/kg (w/w) is based on total radioactivity in whole-body, rather than parent substance residues on a lipid-normalized tissue basis. The supporting study of Neely et al. (1974) derives a steady-state BCF value of 438 in trout, which is based on measured biphenyl concentrations in exposure water and in edible fillet tissue (wet wt.).
The Key Study conducted by Takahashi and Blanchard (1974), yielding a
whole-body BCF of 1900 L/kg (ww), is based on total accumulated
radioactivity in whole fish, and thus represents a worst-case
representation of bioconcentration in fish.The Supporting Study of Neely
et al. (1974) derives a steady-state BCF value of 438 in trout, which is
based on measured biphenyl concentrations in exposure water and in
edible fish fillet tissue (wet wt.). Two other relevant and reliable
studies are reported, describing accumulation of total applied
radioactivity as biphenyl in oyster and in trout. The study of Williams
et al. provides a similar total radioactivity/total weight BCF value of
2422 L/kg in oyster. The measurement of biphenyl in tissues sampled
after 28 days exposure indicated a lesser BCF value of 110 L/kg. When
placed in biphenyl-free flowing seawater oysters did not eliminate
significant amounts of 14C from soft tissues. Of the total 14C activity
associated with oyster tissues, 6.5% was identified as parent biphenyl
compound, 5.4% as more non-polar materials, and 31.5 % as highly polar
materials (conjugated biphenyl metabolites). 3'- and 4'-hydroxybiphenyl
accounted for less than 1% of the total 14C activity. This study was
also considered reliable and its results will be used as supporting
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