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EC number: 202-163-5
CAS number: 92-52-4
The Key Studies of Kishi et al. (1990) and Southworth and Keller (1986) report measured Koc values in widely varied soils, which range from 876 - 3,300 (log Koc 2.94 - 3.52). Other supporting studies of Saeger et al. indicate log Koc values ranging from 2.16 - 2.38 in various aquatic sediment samples. A QSAR prediction of log Koc = 3.15, using a recently developed QSAR for neutral organics, is also reported by Schüürmann et al. (2006). The average value of eight well-documented log Koc values reported in the Key Studies (ave. log Koc = 3.19) will be used as basis for the Chemical Safety Assessment.
The Key Studies provide the best available and relevant measured values
of log Koc for this substances. Several databases and studies refer to
an experimentally determined log Koc value of 3.27 for biphenyl, which
turns out to be an average of estimated log Koc values determined for
various samples of colloidal organic matter. This 1984 study by Landrum
et al. (Environmental Science and Technology 18:187 -192) has no
similarity to current standardized test guidelines. The experimental
database of U.S. EPA KocWIN refers to Schüürmann et al. (2006),
Schüürmann et al. refer to a publication of Sabljic et al. (1995), which
cites the average log Koc value of Landrum et al. (1984).
Further, several reliable QSAR estimates are available. Using KocWIN
v2.00, which is an approved tool for estimating adsorption coefficients
for organic substances, the log Koc was predicted to be 3.71 based on
first order molecular connectivity index, and 3.47 based on log Kow. A
newly developed QSAR for neutral organics however yields a most likely
more reliable value of 3.15 (Schüürmann et al., 2006).
Three other sources yielded relevant, but non-reliable information. The
environmental fate studies of Saeger et al. (1988a,b,c) – described
under the endpoints on biodegradation – yielded log Koc values of 2.25,
2.16 and 2.27-2.38, respectively. These values could not be considered
reliable because of the interference of other loss processes (e.g.,
volatilization, degradation, adsorption to testing equipment, etc.).
However, the fact that they are lower than the experimentally determined
value as well as the available estimates is completely in line with the
expectations based on the rationale for these studies and therefore
these values can be used in support of the other available information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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