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EC number: 202-163-5
CAS number: 92-52-4
The classification of biphenyl is harmonized both according to the the
CLP and the DSD regulation. In Annex I of the Dangerous Substance
Directive 67/548/EC, biphenyl is classified as N, R50/53. In Annex VI of
the CLP Regulation (EC) 1272/2008, biphenyl is classified as H410
(Aquatic Chronic 1) and also receives the GHS09 pictogram for
This harmonized classification is in accordance with the experimental
test results provided in this dossier. The lowest acute E/LC50 was a
48-h LC50 of 0.36 mg/L for the aquatic invertebrate Daphnia magna, which
is below 1 mg/L, resulting in the R50 classification under the DSD and
the redundant classification as H400 (Aquatic Acute 1) under the CLP
regulation. The classification as R50/53 under the DSD regulation is
based on the fact that, additionally, the substance has a log Kow >= 3
(and the experimentally derived BCF is not <= 100 L/kg). The
classification as H410 under the CLP regulation is based on the fact
that, additionally, the substance has a log Kow >= 4 and a BCF >= 500
L/kg. The key log Kow value for biphenyl used in the CSA is 4.008 at 25°
and the key experimentally derived BCF is 1900 L/kg, which are both
above the thresholds proposed by both the DSD and the CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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