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EC number: 202-163-5
CAS number: 92-52-4
Results of concentration analysis:
The analytically determined concentration of the test material in the
dosing solutions used for the micronucleus test ranged from 98.96 to
100.7% of the targeted values (The Dow Chemical Company, 2006 - Dose
Confirmation (Study 061100; Biphenyl FP)).
The treatments did not have remarkable effect on the body weight of the
animals. There were indications of toxicity upon daily observation
during the in-life portion of the micronucleus test at the highest dose
of 800 mg/kg bw/day in males and female mice. Decreased activity,
crouched posture, and cold to touch were among the observations noted at
this dose level. Accidental deaths caused by oral gavage errors occured
in a negative control male mouse and a male high dose mouse. At the
highest dose of 800 mg/kg bw/day, a significant decrease in body
temperature of approximately 6.4°C in males and 8.5°C in females was
observed at 2 hours after the initial dose. Decreases in body
temperature persisted for > or = 5 hours; however, they recovered prior
to the second day of dosing. At the 400 and 200 mg/kg bw/day dose
levels, there were minimal to no decreases in body temperature.
Summary of Micronucleated Polychromatic Erythrocytes (MN-PCE)
Frequencies and % Polychromatic Erythrocytes (% PCE) - 5 males or
CP = Cyclophosphamide monohydrate (positive control)
*: Mice were dosed with the vehicle (corn oil)
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