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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP study. Documentation insufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
biphenyl
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
corn oil
Details on dermal exposure:
no data
Duration of exposure:
24h
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
1 female for dose of 5010 mg/kg
1 male and 1 female for dose of 7940 mg/kg
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 010 mg/kg bw

Applicant's summary and conclusion

Conclusions:
The dermal LD50 after 24 hours of exposure to biphenyl is greater than 5010 mg/kg bw in New-Zealand albino rabbits.

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