Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP study. Documentation not sufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20% solution in corn oil

Doses:
2000, 2510, 3160 and 3980 mg/kg
No. of animals per sex per dose:
3 males for doses 2000 and 3160 mg/kg and 2 males for doses 2510 and 3980 mg/kg
3 females for doses 2510 and 3980 mg/kg and 2 females for doses 2000 and 3160 mg/kg
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 400 mg/kg bw
95% CL:
2 180 - 2 640
Remarks on result:
other: One to five days with most deaths occurring within two days.

Applicant's summary and conclusion

Conclusions:
The oral LD50 is 2400 mg/kg bw with a 95% confidence limit of 2180 to 2640 mg/kg in Sprague Dawley rats (results for combined sexes).