Registration Dossier
Registration Dossier
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EC number: 202-163-5 | CAS number: 92-52-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP study. Documentation not sufficient for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Biphenyl
- EC Number:
- 202-163-5
- EC Name:
- Biphenyl
- Cas Number:
- 92-52-4
- Molecular formula:
- C12H10
- IUPAC Name:
- 1,1'-biphenyl
- Details on test material:
- - Name of test material (as cited in study report): biphenyl
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% solution in corn oil
- Doses:
- 2000, 2510, 3160 and 3980 mg/kg
- No. of animals per sex per dose:
- 3 males for doses 2000 and 3160 mg/kg and 2 males for doses 2510 and 3980 mg/kg
3 females for doses 2510 and 3980 mg/kg and 2 females for doses 2000 and 3160 mg/kg - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 400 mg/kg bw
- 95% CL:
- 2 180 - 2 640
- Remarks on result:
- other: One to five days with most deaths occurring within two days.
Applicant's summary and conclusion
- Conclusions:
- The oral LD50 is 2400 mg/kg bw with a 95% confidence limit of 2180 to 2640 mg/kg in Sprague Dawley rats (results for combined sexes).
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