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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP study. Documentation not sufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20% solution in corn oil

Doses:
2000, 2510, 3160 and 3980 mg/kg
No. of animals per sex per dose:
3 males for doses 2000 and 3160 mg/kg and 2 males for doses 2510 and 3980 mg/kg
3 females for doses 2510 and 3980 mg/kg and 2 females for doses 2000 and 3160 mg/kg
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 400 mg/kg bw
95% CL:
2 180 - 2 640
Remarks on result:
other: One to five days with most deaths occurring within two days.

Applicant's summary and conclusion

Conclusions:
The oral LD50 is 2400 mg/kg bw with a 95% confidence limit of 2180 to 2640 mg/kg in Sprague Dawley rats (results for combined sexes).