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EC number: 202-163-5
CAS number: 92-52-4
A specialist in occupational medicine examined the cases. Medical
records were collected from the neurological departments of local
hospitals. A neurologist at the Institute of Clinical Neuroscience at
the University Hospital also examined the cases and files for a second
opinion. Only cases with at least two of the classical signs (tremor,
rigidity, hypokinesia) and a positive reduction in signs with levodopa
treatment were included. Cases with atypical neurological signs or
treatment with neuroleptic drugs were excluded.
The report by Wastensson et al. (2006) has identified a cluster of 5
cases of PD in living male mill worker employees from Sweden who worked
there at some time from 1954 to 1970. These cases were found in a group
of 255 biphenyl-exposed workers still living in 2002 that were < 80
years of age and with screened job titles. Deceased workers were not
considered in the interpretation and analysis. There may have been more
workers in this facility that were not included. Overall, these
omissions may have biased the expected PD incidence case umbers. The
number of expected cases in the exposed group was estimated by authors
to be 0.9, resulting in a reported relative risk of 5.6 (95% CI 1.8–13).
Exposure to biphenyl may have contributed to this PD cluster, but chance
was given as an alternative explanation by the authors.
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