Registration Dossier
Registration Dossier
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EC number: 202-163-5 | CAS number: 92-52-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP study. Documentation insufficient for an assessment of reliability.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- no
Test material
- Reference substance name:
- Biphenyl
- EC Number:
- 202-163-5
- EC Name:
- Biphenyl
- Cas Number:
- 92-52-4
- Molecular formula:
- C12H10
- IUPAC Name:
- 1,1'-biphenyl
- Details on test material:
- - Name of test material (as cited in study report): biphenyl
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg applied as finely ground sample - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- at 1, 24, 48, 72, 120 and 168 hrs
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- No data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 11.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 8
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 0.6
- Max. score:
- 110
- Reversibility:
- fully reversible within: 72 hours
- Irritant / corrosive response data:
- Immediate: discomfort was slight
10 Min.: Slight erythema, copious discharge
1 hour: Moderate erythema, very slight edema in five instances, copious discharge
24 hours: Slight erythema, copious discharge with slight whitish exudate
48 hours: Gradual improvement
72 hours: All scored zero
Any other information on results incl. tables
Immediate: discomfort was slight
10 Min.: Slight erythema, copious discharge
1 hour: Moderate erythema, very slight edema in five instances, copious discharge
24 hours: Slight erythema, copious discharge with slight whitish exudate
48 hours: Gradual improvement
72 hours: All scored zero
Applicant's summary and conclusion
- Conclusions:
- Slight erythema was observed with copious discharge at 1 and 24 hours (after 24 hours exposure to biphenyl). At 48 hours, gradual improvement was observed and the observed effects were fully reversible within 72 hours.
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