Registration Dossier
Registration Dossier
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EC number: 202-163-5 | CAS number: 92-52-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No GLP. Documentation insufficient for assessment of reliability.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- yes
Test material
- Reference substance name:
- Biphenyl
- EC Number:
- 202-163-5
- EC Name:
- Biphenyl
- Cas Number:
- 92-52-4
- Molecular formula:
- C12H10
- IUPAC Name:
- 1,1'-biphenyl
- Details on test material:
- - Name of test material (as cited in study report): biphenyl
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Intact skin served as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g (moistened with water) - Duration of treatment / exposure:
- 24h
- Observation period:
- up to 10 days
- Number of animals:
- 6
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- for 24 and 72 hours
- Time point:
- other: 24 h, 72 h
- Score:
- 0.3
- Max. score:
- 8
- Irritant / corrosive response data:
- Skin flaked off in seven to ten days.
- Other effects:
- Slight defatting effect. There was no injury in depth.
Applicant's summary and conclusion
- Conclusions:
- Biphenyl was not irritating after 24 hours of exposure to New Zealand albino rabbit skin (0.5 gram applied as ground sample moistened with water). Slight defatting effect - skin flaked off in seven to ten days. There was no injury in depth.
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