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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP. Documentation insufficient for assessment of reliability.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded skin
Vehicle:
unchanged (no vehicle)
Controls:
other: Intact skin served as a control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g (moistened with water)
Duration of treatment / exposure:
24h
Observation period:
up to 10 days
Number of animals:
6
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Remarks:
for 24 and 72 hours
Time point:
other: 24 h, 72 h
Score:
0.3
Max. score:
8
Irritant / corrosive response data:
Skin flaked off in seven to ten days.
Other effects:
Slight defatting effect. There was no injury in depth.

Applicant's summary and conclusion

Conclusions:
Biphenyl was not irritating after 24 hours of exposure to New Zealand albino rabbit skin (0.5 gram applied as ground sample moistened with water). Slight defatting effect - skin flaked off in seven to ten days. There was no injury in depth.