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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
RS-Freetext:---Maternal toxicity:450 mg-group: 4/25 died,significant reduction in periodic maternal body weight andweight gain during dosing, reduction of food consumption,clinical signs: at 450 mg/kg bwhypoactivity, ataxia, tremor, twitches, prone positioning,audible respiration, perioral wetness, for all groups: gestational parameters uneffected, no earlydelivery, no abortion;---Evaluation of offspring:450 mg/kg bw: slight fetotoxicity:one visceral variation: dileted lateral ventricles of thebrain with no tissue compression;NOEL (maternal): 175.0 mg/kg bw/dayNOEL (developmental): 175.0 mg/kg bw/day
Developmental toxicity study according to TSCA Health Effect Guidelines
for Specific Organ/Tissue Toxicity - Developmental Toxicity (EPA 1984,
Administration of o-cresol by gavage to time-pregnant Sprague-Dawley
rats during organogenesis at 0.0, 30.0, 175.0, 450.0 mg/kg bw/d resulted
in significant maternal toxicity at 450 mg/kg bw/d including treatment
related clinical signs (hypoactivity, ataxia, tremor, twitches, prone
positioning, audible respiration, perioral wetness), mortality of 4
dams, statistically significant reduction in body weights and body
weight gain (NOAEL (maternal toxicity) 175 mg/kg bw/d). Slight
fetotoxicity only at 450 mg/kg bw/d as one visceral variation (dilateted
lateral ventricles of the brain with no tissue compression). Thus the
NOAEL (developmental toxicity) is 175 mg/kg bw/d.
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