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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient information for evaluation

Data source

Reference
Reference Type:
publication
Title:
Bio-Fax data sheet: o-cresol
Author:
Industrial Bio-Test Laboratories Inc.
Year:
1969
Bibliographic source:
Data sheet no 4-5/69, Industrial Bio-Test Laboratories Inc. Northbrook, Ill, USA

Materials and methods

Principles of method if other than guideline:
Method: application of the undiluted substance on shaved intact or abraded skin areas, coverage not mentioned, reading 24,48, 72 hours
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: o-cresol, no data on purity, MP 30 °C

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
no further information

Test system

Type of coverage:
not specified
Preparation of test site:
other: shaved : intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
no data
Observation period:
72 hours
Number of animals:
6
Details on study design:
evaluation of erythema and edema

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: mean score of each animals
Time point:
other: abraded and intact skin: after 72 hours
Score:
ca. 4
Max. score:
4
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal: mean score of each animal
Time point:
other: abraded and intact skin: after 72 hours
Score:
ca. 4
Max. score:
4
Reversibility:
no data
Irritation parameter:
overall irritation score
Basis:
other: mean value overall animals
Time point:
other: abraded and intacxt skin: after 72 hours
Score:
ca. 8
Max. score:
8
Reversibility:
no data
Irritant / corrosive response data:
no further information
Other effects:
no further information

Any other information on results incl. tables

RS-Freetext:
intact and abraded skin:
total irritation score: 8.00/8.00

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Executive summary:

Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading 24, 48, 72 hours post application yielded mean irritation score: 8 of max 8. Reversibility is not reported (Industrial Biotest Laboratories 1969).