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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
Most critical cresols:skin irritation: corrosive (o-cresol)eye irritation: corrosive (o-cresol)
There is no study according to the current OECD test guideline but
the studies, which were chosen as key studies, are adequately documented
and are considered of sufficient quality to allow an evaluation of this
The most critical component of the cresols was with the o-cresol
which was corrosive to the skin and the eye of rabbits.
0.5 mL undiluted o-cresol was applied to the intact and abraded
skin of 6 rabbits and readings were made 24, 48 and 72 hours after
application. o-cresol caused within 24 hours severe erythema and edema
in each rabbit (mean score 8.00 of 8.00 [max], Ind. Bio-test Lab Inc
1969). A study with m-cresol was performed where 0.5 mL of the undiluted
test substance was applied to the intact and to the abraded skin of 6
rabbits (Ind. Bio-test Lab Inc 1969). At the observation time of 24
hours after application all animals showed erythema (score 4 of max.4)
and edema (score 4 of max.4) that persisted to the second observation
time point after 72 hours. No tissue destruction and /or necrosis had
been reported. In another study, application of 0.5 ml undiluted
p-cresol on shaved intact or abraded rabbit skin areas, coverage not
mentioned, and reading up to 72 hours post application yielded in a mean
irritation score of 8 of max 8 respectively and reversibility was not
reported (Ind Bio-test Lab Inc 1969).
Application of o-cresol into the conjunctival sac of the rabbits
eyes resulted in severe irritation (mean score: 91.3 of 110[max]).
Recovery was not reported (Ind. Bio-test Lab Inc 1969). Based on the
results in these studies o-cresol is evaluated as corrosive. Application
of 0.5 ml of m-cresol or 0.1 ml p-cresol into the eye of rabbits and
observation up to 72 hours post application resulted in mean irritation
score of 87.3 and 89 respectively of max 110 accounting for severe
irritancy. Reversibility was not reported (Ind Bio-test Lab Inc 1969).
Because of the missing data for the exposure time cresols have to be
classified according to:
DSD: C, R34: Causes burns;
CLP: Category 1B, H314: Causes severe skin burns and eye damage
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