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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: no information about strain used, exposure time : 1 hr, only one concentration

Data source

Reference
Reference Type:
publication
Title:
Bio fax data sheet: m-cresol
Author:
Industrial Bio-test Laboratory Inc.
Year:
1969
Bibliographic source:
Industrial Bio-test Laboratory Inc, Northbrook, Ill/USA, Data sheet no 3-5/69

Materials and methods

Principles of method if other than guideline:
Method: other: 6 rats exposed to 0.71 mg/l for 1 hr, room temperature, up to 14 d post exposure observation, gross necropsy
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: m-cresol, M.p.: 11-12 C; B.P.: 202.8 C

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 212 g
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: air
Details on inhalation exposure:
CONDITIONS:
Room temperature
Total air flow: 10.0 lpm
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 1 h
Concentrations:
0.71 mg/l
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations daily
- weighing: at the end of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 0.71 mg/L air
Exp. duration:
1 h
Mortality:
0/6
Clinical signs:
other: none mentioned
Body weight:
mean weight: initial: 212 g; at termination of the study: 256 g
Gross pathology:
no significant findings
Other findings:
none

Any other information on results incl. tables

RS-Freetext:
Mortality. 0/6; signs of intoxication: none; gross autopsy:
no significant findings

Applicant's summary and conclusion

Executive summary:

No mortality occurred following the exposure of 6 rats to 0.71 mg/l for 1 hr.and within the 14 day observation period. Clinical signs or findings following sacrifice were not reported.