Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
284-892-9
CAS no.:
84989-04-8
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Organic
Registered compositions:
3
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may cause genetic defects and may cause cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is toxic to aquatic life with long lasting effects, is harmful if inhaled and is suspected of causing genetic defects.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance causes serious eye damage.

Breakdown of all 4 C&L notifications submitted to ECHA

Acute Tox. 3 H301
Acute Tox. 3 H311
Skin Corr. 1B H314
Aquatic Chronic 2 H411
Acute Tox. 4 H332
Muta. 2 H341
Eye Dam. 1 H318
Muta. 1B H340 Harmonised Classification
Carc. 1B H350 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 3 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000 - 10 000 tonnes per year.

This substance is used in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers, coating products and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: plastic products and chemicals.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals, closed processes with no likelihood of exposure, treatment of articles by dipping and pouring, laboratory work, industrial spraying, transfer of substance into small containers and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Immediately call a poison center or doctor/physician.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • COVANCE CLINICAL DEVELOPMENT SA 087, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • DEZA a.s., Masarykova 753 75701 Valasske Mezirici Czech Republic
  • ELANTAS Europe S.R.L., Strada Antolini n.1 43044 Collecchio, frazione Lemignano (PR) Emilia-Romagna Italy

Substance names and other identifiers

[The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.]
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
C&L Inventory
Distillate Phenols
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
C&L Inventory
Tar acids, methylphenol fraction
EC Inventory, C&L Inventory, REACH pre-registration
(3- ja 4-metüülfenoolirikas tõrvahappe fraktsioon, mis saadakse madalatemperatuurse kivisöetõrva toortõrvahapete destillatsioonil.) (et)
C&L Inventory
(Frakcija katranske kiseline bogata 3- i 4-metilfenolom, regenerirana destilacijom sirovih katranskih kiselina niskotemperaturnog ugljenog katrana.) (hr)
C&L Inventory
[3- un 4-metilfenolu bagātīgi saturoša darvas skābes frakcija, reģenerēta, zemā temperatūrā destilējot akmeņogļu darvas darvas skābes jēlfrakciju.] (lv)
C&L Inventory
[Deguto rūgščių frakcija, turinti daug 3- ir 4-metilfenolių, gaunama distiliuojant žematemperatūrio akmens anglių deguto žalias deguto rūgštis.] (lt)
C&L Inventory
[die an 3- und 4-Methylphenol reiche Teersäuren-Fraktion, die durch Destillation der rohen Teersäuren von Niedertemperaturkohlenteer gewonnen wird] (de)
C&L Inventory
[Fracţia acidului gudronic bogată în 3-şi 4-metilfenol, recuperată prin distilarea acizilor gudronici din gudronul de cărbune brut cu temperatură joasă.] (ro)
C&L Inventory
[Frakce kyselých složek dehtu bohatá na 3- a 4-methylfenol, získaná destilací nízkoteplotních surových kyselých složek dehtu.] (cs)
C&L Inventory
[Frakcia dechtových kyselín bohatá na 3- a 4-metylfenol, ktorá sa získava destiláciou zo surových dechtových kyselín z nízkoteplotného uhoľného dechtu.] (sk)
C&L Inventory
[Frakcija katranskih kislin bogatih s tri- in štiri-metilfenolom, ki je bila pridobljena z destilacijo surovih katranskih kislin nizkotemperaturnega premogovega katrana.] (sl)
C&L Inventory
[Fraksjon av tjæresyre rik på 3- og 4-metylfenol, gjenvunnet ved destillasjon av råtjæresyrer fra lavtemperaturstenkulltjære.] (no)
C&L Inventory
[Kátrány sav frakció, mely 3- és 4-metilfenolban gazdag. Alacsony hőmérsékletű kőszénkátrányból származó nyers kátrány sav frakciók desztillációjával nyerik.] (hu)
C&L Inventory
[To κλάσμα των οξέων πίσσας, πλούσιο σε 3- και 4-μεθυλοφαινόλη, που ανακτάται με απόσταξη ακατέργαστων οξέων λιθανθρακόπισσας χαμηλής θερμοκρασίας.] (el)
C&L Inventory
[Фракция на катранени киселини, богата на 3- и 4-метилфенол, получена при дестилация на сурови катранени киселини от нискотемпературен каменовъглен катран.] (bg)
C&L Inventory
acidi di catrame, frazione metilfenolo (it)
C&L Inventory
Acizi gudronici, fracţia metilfenolică (mt)
C&L Inventory
Darvas skābes, metilfenola frakcija (lv)
C&L Inventory
De teerzuurfractie, rijk aan 3- en 4-methylfenol, die wordt verkregen door destillatie van ongezuiverde teerzuren uit lage-temperatuur-koolteer. (nl)
C&L Inventory
dechtové kyseliny, metylfenolová (krezolová) frakcia (sk)
C&L Inventory
Deguto rūgštys, metilfenolių frakcija (lt)
C&L Inventory
Destilat fenola (hr)
C&L Inventory
Destillaatfenoolid (et)
C&L Inventory
destillat fenoler (no)
C&L Inventory
Destillat-Phenole (de)
C&L Inventory
Destillerade fenoler (sv)
C&L Inventory
Destilované fenoly (cs)
C&L Inventory
Destilāta fenoli (lv)
C&L Inventory
Destylaty fenolowe (pl)
C&L Inventory
Distilate fenolice (mt)
C&L Inventory
Fenol párlatok (hu)
C&L Inventory
Fenoldestillater (da)
C&L Inventory
fenoles destilados (es)
C&L Inventory
fenoli distillati (it)
C&L Inventory
Fenolių distiliatai (lt)
C&L Inventory
fenolni destilati (sl)
C&L Inventory
fenolové destiláty (sk)
C&L Inventory
Fenóis destilados (pt)
C&L Inventory
fracción de ácidos de alquitrán, rica en 3- y 4-metilfenol, recuperada por destilación de ácidos de alquitrán de hulla a baja temperatura crudo (es)
C&L Inventory
Fraction des huiles de goudron acides riche en méthyl-3 phénol et en méthyl-4 phénol, récupérée par distillation des huiles acides brutes de goudron de houille à basse température. (fr)
C&L Inventory
Fracção dos ácidos do alcatrão rica em 3- e 4-metilfenóis, obtida por destilação dos ácidos brutos de alcatrão de carvão de baixa temperatura. (pt)
C&L Inventory
Fracţia acidului gudronic bogată în 3-şi 4-metilfenol, recuperată prin distilarea acizilor gudronici din gudronul de cărbune brut cu temperatură joasă. (mt)
C&L Inventory
Frakcja fenoli smołowych bogata w 3- i 4-metylofenole, odzyskiwana przez destylację surowych fenoli niskotemperaturowej smoły węglowej. (pl)
C&L Inventory
Fraktionen af tjæresyre, rig på 3- og 4-methylphenol, genvundet ved destillation af rå tjæresyre fra lavtemperatursstenkulstjære. (da)
C&L Inventory
Frazione di acidi di catrame, ricca di 3- e 4- metilfenolo, recuperata dalla distillazione di acidi di catrame grezzi di catrame di carbone a bassa temperatura. (it)
C&L Inventory
Gedestilleerde fenolen (nl)
C&L Inventory
Huiles de goudron acides, fraction méthylphénol (fr)
C&L Inventory
Katranske kiseline, frakcija metilfenola (hr)
C&L Inventory
katranske kisline, metilfenolna frakcija (sl)
C&L Inventory
Kwasy smołowe, frakcja metylofenolu (pl)
C&L Inventory
Kyselé složky dehtu, methylfenolová frakce (cs)
C&L Inventory
Kátrány savak, metilfenol frakció (hu)
C&L Inventory
Oοξέα πίσσας, κλάσμα μεθυλοφαινόλης (el)
C&L Inventory
phénols distillés (fr)
C&L Inventory
Teersäuren, Methylphenol-Fraktion (de)
C&L Inventory
Teerzuren, methylfenolfractie (nl)
C&L Inventory
Tervahapot, metyylifenolifraktio (fi)
C&L Inventory
Tervahappojen fraktio, joka sisältää runsaasti 3- ja 4-metyylifenolia, kerätty tislaamalla matalan lämpötilan kivihiilitervan raakoja tervahappoja. (fi)
C&L Inventory
Tislefenolit (fi)
C&L Inventory
Tjärsyrefraktion, rik på 3- och 4-metylfenol, erhållen genom destillation av råtjärsyra från lågtemperaturstenkolstjära. (sv)
C&L Inventory
Tjärsyror, metylfenolfraktion (sv)
C&L Inventory
tjæresyrer, methylphenolfraktion (da)
C&L Inventory
tjæresyrer, metylfenolfraksjon (no)
C&L Inventory
Tõrva happed, metüülfenooli fraktsioon (et)
C&L Inventory
ácidos de alquitrán, fracción de metilfenol (es)
C&L Inventory
Ácidos do alcatrão, fracção dos metilfenóis (pt)
C&L Inventory
Απόσταγμα φαινόλης (el)
C&L Inventory
Катранени киселини, фракция на метилфенол (bg)
C&L Inventory
Фенолни дестилати (bg)
C&L Inventory
Tar acids, cresol fraction
Other
Cresol
Registration dossier
Cresol 215-293-2
Registration dossier
Tar acids, methylphenol fraction; Distillate Phenols
Registration dossier
648-120-00-8
Index number
C&L Inventory
84989-04-8
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Melting/freezing point

Study results
  • 5 studies submitted
  • 1 study processed
R Melting / freezing point
-13 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 7 studies submitted
  • 4 studies processed
R Boiling point
200.5 - 201.6 °C @ 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 6 studies submitted
  • 3 studies processed
R Density
1.036 - 1.037 g/cm³ [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 7 studies submitted
  • 4 studies processed
R Vapour pressure
44.8 - 70.4 Pa @ 20 °C [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 5 studies submitted
  • 1 study processed
R Log Pow
1.5 - 2.5 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 5 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
11.3 - 26 g/L @ 20 - 25 °C and pH 7 [5]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 7 studies submitted
  • 4 studies processed
R Flash point
87 - 104 °C [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 5 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
530 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
10.1 - 10.3 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 6 studies submitted
  • 4 studies processed
R kinematic viscosity (in mm²/s)
16.6 - 18.1 [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 17 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 13
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 100 µg/L (1)
Intermittent releases (freshwater) 44 µg/L (1)
Marine water 3 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1.14 mg/L (1)
Sediment (freshwater) 327.83 µg/kg sediment dw (1)
Sediment (marine water) 9.83 µg/kg sediment dw (1)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 57.32 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning -

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 4.4 - 57.5 mg/L [9]
LC50 (48 h) 4.4 - 8.4 mg/L [3]
LC50 (24 h) 4.4 - 9.2 mg/L [3]
LC50 (6 h) 4.7 - 11.4 mg/L [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (32 days) 1.35 mg/L [1]
NOEC (4 days) 300 µg/L [1]
LOEC (32 days) 2.57 mg/L [1]
EC50 (4 days) 5 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC50 (4 days) 5 mg/L [1]
EC50 (48 h) 7.7 mg/L [1]
EC50 (24 h) 14 mg/L [1]
EC0 (48 h) 3.1 mg/L [1]
EC0 (24 h) 6.3 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 7.8 - 21 mg/L [2]
EC10 (48 h) 2.3 - 4.6 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 11
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (14 days) 233 mg/kg soil ww [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.5 mg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: (DNEL) 900 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 900 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 121 - 242 mg/kg bw (rat) [3]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (60 min) 710 mg/m³ air (rat) [1]

inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 1 study processed
P/RResults
LD50 301 mg/kg bw (rabbit) [1]

dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Repeated dose toxicity

Study results
Study data: oral
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 50 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 4
Supporting study 8
Weight of evidence
Other 4
Data waiving
no waivers
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 1
Weight of evidence 1
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant