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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
Most critical values of cresols:oral: LD50 rat 121mg/kg bw (o-cresol)dermal: LD50 rat 301mg/kg bw (p-cresol)inhalation: LC50 rat >710mg/m³ (m-cresol and p-cresol)
Acute oral toxicity:
The most critical value for cresols was reported in the study
performed with o-cresol where the oral LD50 of undiluted o-cresol in
rats was determined to be 121 mg/kg bw. Following oral application the
LD50 in rats was 242 mg/kg bw for undiluted m-cresol and 207 mg/kg bw
for p-cresol. In all 3 studies 5 rats per dose were treated and
mortalities occurred in all except the low dose groups. The observed
signs of intoxication for all cresols included hypoactivity, tremors,
lacrimation, dyspnoea, hemorrhagic rhinitis, convulsions and prostration
observed within 4 hours post dosing. (Ind Bio-test Lab Inc 1969).
Acute dermal toxicity:
The LD50 of p-cresol for acute dermal exposure was the most
critical of the cresols with 301 mg/kg bw. The other cresols revealed
LD50s of 1380 mg/kg bw (o-cresol) and 2050 mg/kg bw (m-cresol). All
studies were performed by Bio-test Lab Inc (1969) on 5 rabbits that
received 4 doses of the cresols respectively. The animals were observed
for 14 days post exposure and mortality and clinical signs were
reported. Mortalities occurred in all dose groups between 215 mg/kg bw
(1 out of 5) and 3160 mg/kg bw (5/5). Clinical signs included
hypoactivity, tremor, convulsion, salivation, dyspnoea, prostration and
additionally the treated skin showed severe erythema and burns in the
high dose groups.
Acute inhalation toxicity:
An acute inhalation study was performed similar to OECD guideline
403 with p-cresol (Ind Bio-test Lab Inc 1969). 6 rats were exposed to
710 mg/m³ for 1 hr at room temperature and observed for clinical signs
or mortality up to 14 days post exposure. Gross necropsy was performed
at the end of the observation period. The same study was performed with
m-cresol where additional information about the airflow of 10.0 Lpm was
reported. The exposure of male rats for 1 hour to 710 mg/m³ m-cresol or
p-cresol led to no mortalities or any clinical signs. These studies
where chosen for the most critical LC50 of cresols because of their
higher reliability in comparison to the other performed study with
o-cresol. 6 male rats were exposed to 1220 mg o-cresol/m³ and
observations for clinical signs, mortality and gross autopsy were
reported. Generalized inactivity and lacrimation were observed at the
first 15-30 minutes of treatment with recovery at treatment day.
Cresols have to be classified according to:
DSD: oral: T, R25: Toxic if swallowed; dermal: T, R24: Toxic in contact
CLP: oral category 3, H301: Toxic if swallowed; dermal category 3, H311:
Toxic in contact with skin
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