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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
NOEC (4 d) = 0.3 mg/L on Gadus morrhua (marine, no guideline, embryo and sac-fry stage)NOEC (32 d) = 1.35 mg/L on Pimephales promelas (freshwater, OECD 210)
Long-term effects of p-cresol to the
freshwater species Pimephales promelas were tested in a study
similar to OECD 210 (Barron and Adelman, 1984). After an exposure period
of 32 d a NOEC of 1.35 mg/L was found. This value is included in the
PNEC derivation for freshwater.
Long-term effects of o-, m-,
and p-cresol to different life stages were measured in a non-guideline
study using fertilized fish eggs and larvae of the marine fish species Gadus
morrhua (Atlantic cod) (Falk-Petersen et al. 1985). Eggs and larvae
were incubated for 4 d (eggs) to 6 d (larvae) and monitored for
sublethal effects during the post-exposure periods of up to 12 d. The
4-d EC50 was >30 mg/L (highest test concentration) for o-, and m-cresol.
From lowest non-lethal effects at 10 mg/L, a NOEC of 3 mg/L was derived
for o-, and m-cresol. The most critical NOEC of 0.3 mg/L was found for
p-cresol. This study is comparable to a short-term toxicity test on
embryo and sac-fry stages (EU Annex V C.15, OECD 212), which would be a
suitable replacement of a true chronic test (EU TGD 2003). It has some
shortcomings regarding documentation and the exposure time is limited to
parts of the observation period. However, as the experimental results of
3 different exposure periods support each other, the test can be used as
"reliable with restrictions".
Comparing results on freshwater and
marine fish species the most sensitive NOEC of 0.3 mg/L was found for
the marine compartment.
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