Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
RS-Freetext:F0-genration:---Mortality during pre-breed period: 450 mg/kg bw/d males: 12/25 and females: 8/25---Signs of intoxication.450 mg/kg bw/d, males and females: hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid respiration, lacrimation, amd perioral wetness occurred immediately after
dosing but did not persist until the next day. ---Mean weight gain in F0 males and F0 females were equivalent across
the groups---Mean body weight, significantly reduced: males: 175 mg-gr., 450 mg-gr., week 13: 489.9 g,470.9 g versus 522 g of controls ---Reproductive parameters for F0 parents at F1 breed:Mating index (males and females), fertility index (males and females) and
gestational index were not affected by treatment.--Body weight development during gestation and lactation was equivalent
across the groups.--F1-pups:-Live-birth index was comparable across the groups, sex ratio was not affected-Survival Indices:4-day-, 7-day-, 14-day- and 21-day-survival indices and lactation index were
equivalent across the groups. 450 mg/kg bw/d,males (pre-breed period): significantly reduced mean body weights:
139.6 g versus 162 g in controls
F1-adult-generation---Signs of intoxication.450 mg/kg bw/d, males and females:hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid
respiration, lacrimation, and perioral wetness 175 mg/kg bw/d:males: perioral wetnessfemales: hypoactivity, ataxia, perioral wetness---Mortality450 mg-group:pre-breed period: 8 males and 14 femalesadditionally:7 males and 9 females died prior to mating, 3 females which were found
pregnant died and another one died during gestation---body weight and weight development females: equivalent across the groupsmales: week 14, low, mid, high dose: 586.6 g, 564.1 g, 494.4 g versus
526.3 g of controls ---Reproductive parameters for F1 parents at F2 breed:Mating index (males and females), fertility index (males and females)
and gestational index were not affected by treatment.--Body weight development during gestation and lactation was equivalent
across the groups.--F2-pups:-Live-birth index was comparable across the groups, sex ratio was not affected-Survival Indices:4-day-, 7-day-, 14-day- and 21-day-survival indices were equivalent across
the groups. lactation index450 mg-group: was significantly reduced (75.5 versus 99.4 in controls)Conclusion: The A/D ratio (the dose level at which there wereno observable effects in offsprings) is less than 1:(30/175) indicating no increased risk to offspring fromo-cresol in the absence of parental effects.
Two-generation reproductive toxicity according to TSCA Health Effects
Test Guideline for specific organ/tissue toxicity -
Reproduction/Fertility effects (EPA, 1983)
Continued administration of o-cresol by gavage for two generations to
Sprague-Dawley rats resulted in general toxicity including increased
mortality at 450 mg/kg bw/d and in clinical signs of toxicity including
hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid
respiration and perioral wetness at >= 175 mg/kg bw/d (NOAEL (genral
toxicity) 30 mg/kg bw/d). No reproductive parameters were affected by
treatment in either of the two generations (NOAEL (fertility) 450 mg/kg
The NOAEL (offspring) is 175 mg/kg bw/d based on significantly reduced
body weights in F1 males and in significantly reduced lactation index
in F2 at 450 mg/kg b
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again