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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
RS-Freetext:F0-genration:---Mortality during pre-breed period: 450 mg/kg bw/d males: 12/25 and females: 8/25---Signs of intoxication.450 mg/kg bw/d, males and females: hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid respiration, lacrimation, amd perioral wetness occurred immediately after
dosing but did not persist until the next day. ---Mean weight gain in F0 males and F0 females were equivalent across
the groups---Mean body weight, significantly reduced: males: 175 mg-gr., 450 mg-gr., week 13: 489.9 g,470.9 g versus 522 g of controls ---Reproductive parameters for F0 parents at F1 breed:Mating index (males and females), fertility index (males and females) and
gestational index were not affected by treatment.--Body weight development during gestation and lactation was equivalent
across the groups.--F1-pups:-Live-birth index was comparable across the groups, sex ratio was not affected-Survival Indices:4-day-, 7-day-, 14-day- and 21-day-survival indices and lactation index were
equivalent across the groups. 450 mg/kg bw/d,males (pre-breed period): significantly reduced mean body weights:
139.6 g versus 162 g in controls
F1-adult-generation---Signs of intoxication.450 mg/kg bw/d, males and females:hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid
respiration, lacrimation, and perioral wetness 175 mg/kg bw/d:males: perioral wetnessfemales: hypoactivity, ataxia, perioral wetness---Mortality450 mg-group:pre-breed period: 8 males and 14 femalesadditionally:7 males and 9 females died prior to mating, 3 females which were found
pregnant died and another one died during gestation---body weight and weight development females: equivalent across the groupsmales: week 14, low, mid, high dose: 586.6 g, 564.1 g, 494.4 g versus
526.3 g of controls ---Reproductive parameters for F1 parents at F2 breed:Mating index (males and females), fertility index (males and females)
and gestational index were not affected by treatment.--Body weight development during gestation and lactation was equivalent
across the groups.--F2-pups:-Live-birth index was comparable across the groups, sex ratio was not affected-Survival Indices:4-day-, 7-day-, 14-day- and 21-day-survival indices were equivalent across
the groups. lactation index450 mg-group: was significantly reduced (75.5 versus 99.4 in controls)Conclusion: The A/D ratio (the dose level at which there wereno observable effects in offsprings) is less than 1:(30/175) indicating no increased risk to offspring fromo-cresol in the absence of parental effects.
Two-generation reproductive toxicity according to TSCA Health Effects
Test Guideline for specific organ/tissue toxicity -
Reproduction/Fertility effects (EPA, 1983)
Continued administration of o-cresol by gavage for two generations to
Sprague-Dawley rats resulted in general toxicity including increased
mortality at 450 mg/kg bw/d and in clinical signs of toxicity including
hypoactivity, ataxia, twitches, tremors, prostration, gasping, rapid
respiration and perioral wetness at >= 175 mg/kg bw/d (NOAEL (genral
toxicity) 30 mg/kg bw/d). No reproductive parameters were affected by
treatment in either of the two generations (NOAEL (fertility) 450 mg/kg
The NOAEL (offspring) is 175 mg/kg bw/d based on significantly reduced
body weights in F1 males and in significantly reduced lactation index
in F2 at 450 mg/kg b
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