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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
oral: 90d rat: NOAEL 50 mg/kg bw/day (o-, m- and p-cresol) dermal: cresols are corrosiveinhalation: no valid data available
The NOAEL of cresols was 50 mg/kg bw/day achieved in 3 independent
90 day subchronic studies with all three cresol isomers respectively.
The LOAEL that was derived from these studies was 150 mg/kg bw/day.
According to Sontag JM, Page NP, Saffotti U (NCI, DHEW Publication
No (NIH)78-ß01 Guidelines for Carcinogen Bioassay in small rodents) male
and female rats were applied with 0, 50, 175, 600 mg o-cresol/kg bw/day
by gavage for 13 weeks. The NOAEL was determined to be 50 mg/kg bw/day
based on adverse effects from the dose level of 175 mg/kg bw/day (LOAEL)
onwards including central nervous system depression and statistically
significant reduction in body weight and body weight gain (RTI 1988).
In a study according to OECD TG 408, male and female Sprague
Dawley rats received 0, 50, 150, 450 mg m-cresol/kg bw/day diluted in
corn oil for a period of 13 weeks by gavage. Dose-dependant body weight
decrease resulted in a NOAEL (male rat) of 50 mg/kg bw/day. The NOAEL
(female rat) was 150 mg/kg bw/day based on reduced body weight gain in
the highest dose group (RTI 1988). The LOAELs were therfore 150 mg/kg
bw/day for male and 450 mg/kg bw/day for female rats.
In a subchronic toxicity study according to OECD TG 408 p-cresol
was administered daily to male and female Sprague-Dawley rats by gavage
at dose levels of 0, 50, 175 , 600 mg/kg bw/day diluted in corn oil
(RTI1988). Based on increased mortality, clinical signs including
lethargy, exessive salivation, tremor and occasional convulsions and
comas, hepatotoxicity and nephrotoxicity from 175 mg/kg bw/d onwards.
The NOAEL was determined to be 50 mg/kg bw/day and the LOAEL 175 mg/kg
There are no valid data available to characterize the repeated
dosing using the dermal application route. In addition, cresols are
known to be corrosive. Adequate inhalation studies are also
not not available.
Cresols have not to be classified according to DSD and CLP because the
guidance values were lower than the lowest effective dose level (LOAEL:
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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