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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
All cresol isomers are absorbed across the respiratory and
gastrointestinal tract and through the intact skin (Morinaga 2004, WHO
Limited data indicate that cresols are widely distributed throughout the
body after uptake.
Cresols are mainly conjugated with glucuronic acid and inorganic sulfate
and excreted as conjugates with the urine. Minor pathways for m- and
p-cresol include hydroxylation of the benzene ring. In addition to
urinary excretion, cresols are excreted in the bile, but most part
undergo enterohepatic circulation (WHO 1995).
For p-cresol, side-chain oxidation to p-hydroxy benzoic acid (Bray et al
1950) and, in vitro, oxidation to a reactive quinone methide
intermediate was found in the rat liver slices (Thompson et al 1996). In
addition, p-cresol is an endogenous product for protein breakdown in
humans (WHO 1995).
Significant amounts of o-cresol are excreted in the bile but most of it
is re-absorbed from the intestine. The main route of excretion is renal
elimination (WHO 1995).
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