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Registration Dossier
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EC number: 284-892-9 | CAS number: 84989-04-8 The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Absorption:
All cresol isomers are absorbed across the respiratory and gastrointestinal tract and through the intact skin (Morinaga 2004, WHO 1995).
Distribution:
Limited data indicate that cresols are widely distributed throughout the body after uptake.
Metabolism:
Cresols are mainly conjugated with glucuronic acid and inorganic sulfate and excreted as conjugates with the urine. Minor pathways for m- and p-cresol include hydroxylation of the benzene ring. In addition to urinary excretion, cresols are excreted in the bile, but most part undergo enterohepatic circulation (WHO 1995).
For p-cresol, side-chain oxidation to p-hydroxy benzoic acid (Bray et al 1950) and, in vitro, oxidation to a reactive quinone methide intermediate was found in the rat liver slices (Thompson et al 1996). In addition, p-cresol is an endogenous product for protein breakdown in humans (WHO 1995).
Excretion:
Significant amounts of o-cresol are excreted in the bile but most of it is re-absorbed from the intestine. The main route of excretion is renal elimination (WHO 1995).
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