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EC number: 284-892-9
CAS number: 84989-04-8
The fraction of tar acid rich in 3- and 4-methylphenol, recovered by distillation of low-temperature coal tar crude tar acids.
The following DN(M)EL could not be derived:
DN(M)ELs for acute / short term exposure, systemic effect
Dermal DN(M)EL for acute / short term exposure, local effect
Dermal DN(M)EL for long-term exposure, systemic effect
Dermal DN(M)EL for long-term exposure, local effect
The toxic effect of mixed cresol which is critical for the
establishing a threshold value is the local highly irritating or even
caustic property of mixed cresols to skin and mucous membranes.
However, there are no valid data in animals available for repeated
dose toxicity using the inhalation route or the dermal route of
exposure. Therefore dose-response information with respect to irritating
or corrosive effects is not available.
In addition, as the test results from the available acute toxicity
studies using inhalational or dermal exposure route are not graded due
to the observed irritating effects, they also do not provide a basis for
setting a DNEL. Thus, a threshold cannot be given and DNELs cannot be
However, regularly performed occupational medical surveillance in
a plant indid not report of complaints from irritating effects from
workers (Currenta 2008) with measured maximal occupational cresol
concentrations in the air of 0.9 mg/m³ which is regarded to be the
NOAEC. With respect to the available MAK-values of strong organic acids
(0.1 -25 mg/m³), this NOAEC is in the lower range of the MAK values for
the strong organic acids and therefore the NOAEC of 0.9 mg/m³ can be
used as surrogate for DNEL for local effects as a conservative approach.
With respect to dermal systemic toxicity the inhalation DNEL long
term can be taken into account.
It needs to be taken into consideration that mixed cresols are
already classified as corrosive and labelled with R 34 = causes burns
(R67/548/EEC, 19. ATP).Those substances are allocated to the moderate
hazard band with defined risk management measures and operational
conditions on the bases that exposure to such strong irritant substances
should be well controlled.
There are no consumer uses and no consumer exposure to mixed
cresol. Therefore DNELs for the general public have not to be derived.
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