Registration Dossier
Registration Dossier
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EC number: 201-549-0 | CAS number: 84-65-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974-1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: US study, brief summary report available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The dust was generated by passing a stream of clean, dry air (-40°C dew-point) through a Ferris wheel generator containing the undiluted test material and into the test material. 4 hours exposure followed by 14 days observation period.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Anthraquinone
- EC Number:
- 201-549-0
- EC Name:
- Anthraquinone
- Cas Number:
- 84-65-1
- Molecular formula:
- C14H8O2
- IUPAC Name:
- 9,10-dihydroanthracene-9,10-dione
- Details on test material:
- A.Q. Rec. Dry, 234/74
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BLU: (LE)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 244,0 mg/m3 air (maximum attainable concentration)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 244 mg/m³ air
- Based on:
- not specified
- Exp. duration:
- 4 h
- Mortality:
- no
- Clinical signs:
- other: There were no untoward reactions during exposure or the 14-day observation period which followed.
- Body weight:
- The average two-week body weight gains were within the normal limits.
- Gross pathology:
- Necropsy, performed on all rats at the end of observation period, did not reveal any gross pathologic alterations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
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