Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974-1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: US study, brief summary report available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The dust was generated by passing a stream of clean, dry air (-40°C dew-point) through a Ferris wheel generator containing the undiluted test material and into the test material. 4 hours exposure followed by 14 days observation period.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
A.Q. Rec. Dry, 234/74

Test animals

Species:
rat
Strain:
other: BLU: (LE)
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
clean air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 4 h
Concentrations:
244,0 mg/m3 air (maximum attainable concentration)
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
>= 244 mg/m³ air
Based on:
not specified
Exp. duration:
4 h
Mortality:
no
Clinical signs:
There were no untoward reactions during exposure or the 14-day observation period which followed.
Body weight:
The average two-week body weight gains were within the normal limits.
Gross pathology:
Necropsy, performed on all rats at the end of observation period, did not reveal any gross pathologic alterations.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: not specified