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EC number: 201-549-0
CAS number: 84-65-1
are no appropriate data available for PNECs calculations. Experimental
short term toxicity studies are waived because of high insolubility of
anthraquinone in water (In accordance with REACH Regulation (EC) No
1907/2006, Annex VII and Annex VIII). Seeing that the solubility is 74.6
micrograms per liter, substance meets the criteria for insolubility. The
long-term aquatic toxicity study was performed according to testing
proposal (study was performed according to method C.20 – Daphnia magna
Reproduction Test, Council Regulation (EC) No. 440/2008, published in
O.J.L 142, 2008).
are five acute toxicity studies available (three for fish, one acute
toxicity study to freshwater invertebrates and one for marine organisms)
with reliable results and where selection of the test concentrations was
based on the limit of water solubility of anthraquinone. Based on these
data it was established that under the conditions maintained during the
studies anthraquinone is not acutely toxic to fish, daphnids and eastern
oysters at and below the material's limit of water solubility.
same result was obtained in long-term reproduction test on Daphnia
magna, where the anthraquinone do not display toxicity at and below the
water solubility limit. The highest calculated reduction in reproductive
output was 1.8 % and the exact values of EC50could not be
calculated on the basis of data acquired (21 d–EC50>0.0539
mg.L-1 (average measured concentration)). The assumed value of EC50 is
higher than solubility of the test substance in testing medium, no
further testing is needed.
substance is found to be non toxic in
acute and chronic tests at
its limit of water solubility. Estimation
of PNECs value for aquatic environment is therefore impossible and use
of sediment test should be considered as being more representative of
the real environment.
chemicals may cause adverse effects on microbial activity in STPs it is
necessary to derive a PNECmicroorganisms. The PNECmicroorganismswill
be used for the calculation of the PEC/PNEC ratio concerning microbial
activity in STPs.
No reliable standard microbial inhibition
test data are available. Results of toxicity study of anthraquinone (AQ)
to microorganisms are above water solubility, thus the test result has
to be considered as unreliable. Estimation of PNECs value for STP is
therefore impossible. Although AQ is found to be nontoxic in acute and
chronic tests at its limit of water solubility there is still a
potential risk for water, and environmental exposure must therefore be
minimised with appropriate risk management measures.
result from whole-sediment test with benthic organisms is available the
PNECsed has to be derived from this test using appropriate
is available one study on sub-chronic toxicity of sediment-sorbed to Chironomus
tentans under flow-through conditions (Springborn
Laboratories Inc., 1989).
MATC - Maximum Acceptable Toxicant Concentration (concentration range
encompassing the highest mean measured concentration that has no
significant effect on the test organism performance and the lowest mean
measured concentration that significantly affects the exposed organisms)
≥ 200 mg/kg sediment dw was determined in the study.
is the geometric mean of the NOEC and the LOEC. If in the test report
only the MATC is presented, the MATC can be divided by √2 to derive a
PNECsedimentis derived from the available NOEC≥141.42mg/kg
sediment dw (MATC≥
200 mg/kg sediment dw) obtained in
sub-chronic test with Chironomus
tentans by application of the
assessment factor of 100 and is then expressed as:
water= 1.414 mg/kg
of dry sediment.
PNECmarine sediment is derived by application of the
assessment factor of 1000 to the NOEC value from sub-chronic freshwater
sediment tests and is then expressed as:
water= 0.1414 mg/kg
of dry sediment
are no appropriate data available for PNECs calculationsusing
assessment factor (AF). Experimental
toxicity studies are waived in
accordance with REACH Regulation (EC) No 1907/2006, Annex IX and Annex X
- studies do not need to be conducted if direct and indirect exposure to
the soil compartment is unlikely.
no toxicity data are available for soil organisms, the equilibrium
partitioning method is applied to identify a potential risk to soil
organisms. This method is regarded as a “screening approach” and aquatic
toxicity (PNECwater) is used for calculation. PNECwatercould
not be established due the lack of appropriate data and high
insolubility in water.
PNECoral is ultimately derived from the toxicity data (food
basis) applying an assessment factor.
data on avian toxicity is available then the resulting PNECoralbirdis
derived by applying an assessment factor (AF) to the available toxicity
of AQ to bird Agelaius phoeniceus was reported as LD50=
100 - 300 mg/kg. Using AF 3,000 predefined for acute toxicity data,PNECoralbirdvaried
from 0.033 to 0.1 mg/kg of food.
to Regulation 1272/2008 anthraquinone is not classified as hazardous to
the aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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