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Partition coefficient

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Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2009-2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: giudance followed, no GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Principles of method if other than guideline:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
ca. 3.43
Temp.:
30 °C
pH:
>= 5 - <= 8
Details on results:
Standard deviation: 0.03

Average Partition Coefficient (n-octanol/water): 3.43 ± 0.03

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study
Qualifier:
according to guideline
Guideline:
other: ASTM E 1147-92
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
3.4
Temp.:
30 °C
pH:
7
Details on results:
The log Kow was determined to be 3.4 at pH=7 and a temperature of 30 oC.

Description of key information

3.4 at 30°C, pH=7 
3.43 ±0.03 at 30°C, pH >=5-<=8

Key value for chemical safety assessment

Log Kow (Log Pow):
3.4
at the temperature of:
30 °C

Additional information

Taken value is from GLP study, however other value (log Kow=3.43) is in line with this result.