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EC number: 201-549-0
CAS number: 84-65-1
Based on the results from available
studies on Anthraquinone for worker population, the most sensitive
endpoint was general toxicity, with the endpoint-specific worker-DNELlong-termequal
to 0.0136 mg/kg bw/day for dermal route of exposure and 0.052 mg/m3 for
Since the probability of the peak
inhalatory exposures of workers was confirmed forAnthraquinone, acute
DNEL for inhalatory exposure was obtained by multiplication of DNELlong-terminhalatory
by factor of 5.
Within reproduction toxicity
screening, mainly general toxicity was reported. Mutagenicity and
carcinogenicity data for Anthraquinone were controversial, predominantly
due to the fact that testing material was contaminated witha
structurally related contaminant 9-nitroanthracene. The protocol used,
dose selection and purity (a low level of 9-nitroanthracene as a
contaminant in the sample) may have been critical for the mutagenicity
test results. Highly purified Anthraquinone itself was not proved to be
a mutagen. Anthraquinone considered for this registration is 99.21% pure
and does not contain 9-nitroanthracene as the contaminant. The same
reasoning is valid for carcinogenicity. Based
on the ongoing discussions, recent knowledge, uncertainties involved in
the interpretation of the test results, and considering controversial
data available from in vitro and in
and mutagenicity studies, Anthraquinone is
considered as a non-genotoxic and non-carcinogenic substance.
were derived for workers only.The
exposure of consumers
and men via the environment to Anthraquinone is expected to be negligible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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